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Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs

by Clinical Neuropsychologist | Thursday, July 4, 2024 | Neuroscience

Nature Neuroscience, Published online: 04 July 2024; doi:10.1038/s41593-024-01694-4Bonnavion, Varin and colleagues show that striatal projection neurons that coexpress dopamine D1 and D2 receptors have unique physiological properties and serve as a crucial third...

Phospholipid Scramblase 1 Controls Efficient Neurotransmission and Synaptic Vesicle Retrieval at Cerebellar Synapses

by Clinical Neuropsychologist | Thursday, July 4, 2024 | Neuroscience

Phospholipids (PLs) are asymmetrically distributed at the plasma membrane. This asymmetric lipid distribution is transiently altered during calcium-regulated exocytosis, but the impact of this transient remodeling on presynaptic function is currently unknown. As...

A feature-specific prediction error model explains dopaminergic heterogeneity

by Clinical Neuropsychologist | Wednesday, July 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 July 2024; doi:10.1038/s41593-024-01689-1The authors present a feature-specific prediction error model that explains heterogeneity in dopaminergic signals within and across projection-defined populations. Model-derived...

Central nervous system-associated macrophages modulate the immune response following stroke in aged mice

by Clinical Neuropsychologist | Wednesday, July 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 July 2024; doi:10.1038/s41593-024-01695-3How aging influences peripheral immune cell infiltration and the role of these cells following traumatic injury of the CNS is unclear. Here, the authors show that aging transforms...

Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling

by Clinical Neuropsychologist | Wednesday, July 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 July 2024; doi:10.1038/s41593-024-01699-zThe role of dopaminergic neurons in modulating striatal dynamics on subsecond timescales remains unclear. Long, Lee et al. show that only potentially supra-physiological dopamine levels...
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