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Convergent information flows explain recurring firing patterns in cerebral cortex

by Clinical Neuropsychologist | Monday, December 8, 2025 | Neuroscience

Nature Neuroscience, Published online: 08 December 2025; doi:10.1038/s41593-025-02128-5Reproducible cortical firing patterns arise from hierarchical modular networks shaped by distance-dependent connectivity rather than attractor dynamics, suggesting that cortex is...

Patterned wireless transcranial optogenetics generates artificial perception

by Clinical Neuropsychologist | Monday, December 8, 2025 | Neuroscience

Nature Neuroscience, Published online: 08 December 2025; doi:10.1038/s41593-025-02127-6This work presents a fully implantable wireless optogenetic device that delivers spatiotemporally patterned cortical stimulation through the skull and generates artificial...

The striatal indirect pathway mediates hesitation

by Clinical Neuropsychologist | Friday, December 5, 2025 | Neuroscience

Nature Neuroscience, Published online: 05 December 2025; doi:10.1038/s41593-025-02135-6Hesitation—pausing in the face of uncertainty—is ubiquitous in daily life and disrupted in several psychiatric disorders. Unlike other forms of response inhibition, hesitation is...

Rapid motor skill adjustment is associated with population-level modulation of cerebellar error signals

by Clinical Neuropsychologist | Thursday, December 4, 2025 | Neuroscience

Nature Neuroscience, Published online: 04 December 2025; doi:10.1038/s41593-025-02126-7Populations of cerebellar neurons encode both the size and direction of motor errors, enabling the brain to rapidly adjust movements from one trial to the next. If you do not see...

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation

by Clinical Neuropsychologist | Thursday, December 4, 2025 | Neuroscience

Nature Neuroscience, Published online: 04 December 2025; doi:10.1038/s41593-025-02151-6De la Rosa et al. developed an in vivo CRISPR screening system to dissect macrophage regulation in multiple sclerosis models, revealing key cytokine signaling pathways that control...
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