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Distinct Action Signals by Subregions in the Nucleus Accumbens during STOP-Change Performance

by Clinical Neuropsychologist Online | Thursday, July 18, 2024 | Neuroscience

The nucleus accumbens (NAc) is thought to contribute to motivated behavior by signaling the value of reward-predicting cues and the delivery of anticipated reward. The NAc is subdivided into core and shell, with each region containing different populations of neurons...

Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice

by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Neuroscience

Nature Neuroscience, Published online: 17 July 2024; doi:10.1038/s41593-024-01714-3Perineuronal nets stabilize synapses inhibiting synaptic plasticity. Here, the authors show that perineuronal nets act as a diffusion barrier facilitating astrocytic clearance of...

Unlocking opioid neuropeptide dynamics with genetically encoded biosensors

by Clinical Neuropsychologist Online | Monday, July 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 July 2024; doi:10.1038/s41593-024-01697-1Dong et al. developed and validated κLight, δLight and µLight, a suite of genetically encoded opioid peptide sensors for probing opioid drugs and brain-region/circuit-specific opioid...

A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior

by Clinical Neuropsychologist Online | Monday, July 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 July 2024; doi:10.1038/s41593-024-01715-2Parks, Schneider et al. show that brain states like sleep and wake can be reliably detected from milliseconds of neural activity in local regions in mice. Regions can briefly switch...

Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling

by Clinical Neuropsychologist Online | Thursday, July 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 July 2024; doi:10.1038/s41593-024-01725-0Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cerebellar Purkinje neurons to enhance thirst and maintain fluid...
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