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Glial plasticity dysregulation contributes to learning impairments in the neurogenetic disorder NF1

by Clinical Neuropsychologist Online | Monday, June 3, 2024 | Neuroscience

Nature Neuroscience, Published online: 03 June 2024; doi:10.1038/s41593-024-01667-7Specifically mutating the neurofibromatosis type 1 gene (NF1) in oligodendrocyte precursor cells (OPCs) impairs their adaptive response to neuronal activity and their differentiation...

Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice

by Clinical Neuropsychologist Online | Thursday, May 30, 2024 | Neuroscience

Nature Neuroscience, Published online: 30 May 2024; doi:10.1038/s41593-024-01654-yActivity-dependent oligodendroglial plasticity contributes to neuronal functions. Here the authors show that adaptive oligodendrocyte progenitor cell responses are disrupted in...

A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function

by Clinical Neuropsychologist Online | Monday, May 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 May 2024; doi:10.1038/s41593-024-01659-7Intersectional adeno-associated viruses are important for neuroscience research but can be limited by complex and bulky design parameters. Hughes et al. present a unique and space-saving...

NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling

by Clinical Neuropsychologist Online | Monday, May 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 May 2024; doi:10.1038/s41593-024-01663-xOligodendrocyte-lineage NG2 glia are shown to limit prion-induced neurodegeneration by quenching toxic microglial responses. Their depletion unleashes prostaglandin E2 secretion by...

Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease

by Clinical Neuropsychologist Online | Monday, May 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 May 2024; doi:10.1038/s41593-024-01664-wThe axon guidance receptor Plexin-B1 regulates the cellular interaction of peri-plaque astrocytes with microglia to affect the pathophysiology of Alzheimer’s disease. If you do not see...
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