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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 February 2024; doi:10.1038/s41593-023-01568-1Haynes et al. report a daily, sleep-dependent neuron–glia lipid metabolic cycle. ApoE-dependent lipid transfer from neurons to glia protects neurons from oxidative damage during...

Hunger guides immunity to friend versus foe

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 February 2024; doi:10.1038/s41593-024-01590-xBoth caloric restriction and obesity affect autoimmune diseases. The activation of brainstem neurons in the ventrolateral medulla (VLM) with fasting suppresses experimental...

Glial lipid droplets resolve ROS during sleep

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 February 2024; doi:10.1038/s41593-023-01546-7The Sehgal lab presents data showing that the non-cell autonomous pathway of glial lipid droplet formation occurs during sleep and helps to resolve neuronal reactive oxygen species...

Enhancing GABAergic Tonic Inhibition Reduces Seizure-Like Activity in the Neonatal Mouse Hippocampus and Neocortex

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Approximately one-third of neonatal seizures do not respond to first-line anticonvulsants, including phenobarbital, which enhances phasic inhibition. Whether enhancing tonic inhibition decreases seizure-like activity in the neonate when GABA is mainly depolarizing at...

Auditory Corticofugal Neurons Transmit Auditory and Non-auditory Information During Behavior

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Layer 5 pyramidal neurons of sensory cortices project “corticofugal” axons to myriad sub-cortical targets, thereby broadcasting high-level signals important for perception and learning. Recent studies suggest dendritic Ca2+ spikes as key biophysical...
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