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A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function

by Clinical Neuropsychologist Online | Monday, May 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 May 2024; doi:10.1038/s41593-024-01659-7Intersectional adeno-associated viruses are important for neuroscience research but can be limited by complex and bulky design parameters. Hughes et al. present a unique and space-saving...

NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling

by Clinical Neuropsychologist Online | Monday, May 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 May 2024; doi:10.1038/s41593-024-01663-xOligodendrocyte-lineage NG2 glia are shown to limit prion-induced neurodegeneration by quenching toxic microglial responses. Their depletion unleashes prostaglandin E2 secretion by...

Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease

by Clinical Neuropsychologist Online | Monday, May 27, 2024 | Neuroscience

Nature Neuroscience, Published online: 27 May 2024; doi:10.1038/s41593-024-01664-wThe axon guidance receptor Plexin-B1 regulates the cellular interaction of peri-plaque astrocytes with microglia to affect the pathophysiology of Alzheimer’s disease. If you do not see...

Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus

by Clinical Neuropsychologist Online | Thursday, May 23, 2024 | Neuroscience

Information seeking, such as standing on tiptoes to look around in humans, is observed across animals and helps survival. Its rodent analog—unsupported rearing on hind legs—was a classic model in deciphering neural signals of cognition and is of intense renewed...

Simple Behavioral Analysis (SimBA) as a platform for explainable machine learning in behavioral neuroscience

by Clinical Neuropsychologist Online | Wednesday, May 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 May 2024; doi:10.1038/s41593-024-01649-9This paper presents Simple Behavioral Analysis (SimBA), an open-source platform for automated, explainable machine learning analysis of behavior. SimBA comes with extensive...
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