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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

by Clinical Neuropsychologist Online | Wednesday, April 10, 2024 | Neuroscience

Nature Neuroscience, Published online: 10 April 2024; doi:10.1038/s41593-024-01619-1Using human iPSC-derived and mouse neurons, this study demonstrates that mRNA transport on lysosome-related vesicles is critical for the maintenance of axonal homeostasis and that its...

Advancing the neuroscience of human pregnancy

by Clinical Neuropsychologist Online | Wednesday, April 10, 2024 | Neuroscience

Nature Neuroscience, Published online: 10 April 2024; doi:10.1038/s41593-024-01629-zThe study of the female brain during pregnancy and motherhood is gaining traction, and holds the potential to address the unmet needs of millions of women worldwide. Here we highlight...

Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain

by Clinical Neuropsychologist Online | Tuesday, April 9, 2024 | Neuroscience

Nature Neuroscience, Published online: 09 April 2024; doi:10.1038/s41593-024-01616-4RNA alternative splicing is involved in determining cell identity, but a comprehensive molecular map is missing. Here, the authors provide a human and mouse brain atlas of transcript...

Widespread changes in alternative splicing in developing and adult mouse brain

by Clinical Neuropsychologist Online | Tuesday, April 9, 2024 | Neuroscience

Nature Neuroscience, Published online: 09 April 2024; doi:10.1038/s41593-024-01617-3In the first comprehensive mRNA isoform atlas of the developing and adult mouse brain, we discover that region and age influence the isoform repertoire of cell subtypes. We link peak...

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding

by Clinical Neuropsychologist Online | Monday, April 8, 2024 | Neuroscience

Nature Neuroscience, Published online: 08 April 2024; doi:10.1038/s41593-024-01615-5Precise profiling of dendritic RNA regulation reveals how neuronal depolarization leads to ribosome switching onto short upstream open reading frames and new coding sequences to...
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