by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02117-8Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for...
by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02140-9Syntaxin-1A, a SNARE protein mediating membrane fusion for neurotransmission, forms clusters with unclear functions. Using light-controlled clustering, the authors found that...
by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02119-6The authors developed a mouse brain atlas using local dendritic morphological patterns from 101,136 neurons. This representation not only improves anatomical precision but also...
by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02125-8Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis,...
by Clinical Neuropsychologist | Monday, November 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 November 2025; doi:10.1038/s41593-025-02111-0Examining human brain organoids and ex vivo neonatal murine cortical slices demonstrates that structured neuronal sequences emerge independently of sensory input, highlighting the...
