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Enhancing GABAergic Tonic Inhibition Reduces Seizure-Like Activity in the Neonatal Mouse Hippocampus and Neocortex

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Approximately one-third of neonatal seizures do not respond to first-line anticonvulsants, including phenobarbital, which enhances phasic inhibition. Whether enhancing tonic inhibition decreases seizure-like activity in the neonate when GABA is mainly depolarizing at...

Auditory Corticofugal Neurons Transmit Auditory and Non-auditory Information During Behavior

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Layer 5 pyramidal neurons of sensory cortices project “corticofugal” axons to myriad sub-cortical targets, thereby broadcasting high-level signals important for perception and learning. Recent studies suggest dendritic Ca2+ spikes as key biophysical...

EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Early B-cell factor 1 (EBF1) is a basic helix–loop–helix transcription factor essential for the differentiation of various tissues. Our single-cell RNA sequencing data suggest that Ebf1 is expressed in the sensory epithelium of the mouse inner ear. Here, we found that...

The Neural Dynamics of Face Ensemble and Central Face Processing

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Extensive work has investigated the neural processing of single faces, including the role of shape and surface properties. However, much less is known about the neural basis of face ensemble perception (e.g., simultaneously viewing several faces in a crowd)....

Visual Stimuli Modulate Local Field Potentials But Drive No High-Frequency Activity in Human Auditory Cortex

by Clinical Neuropsychologist Online | Thursday, February 15, 2024 | Neuroscience

Neuroimaging studies suggest cross-sensory visual influences in human auditory cortices (ACs). Whether these influences reflect active visual processing in human ACs, which drives neuronal firing and concurrent broadband high-frequency activity (BHFA; >70 Hz), or...
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