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Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function

by Clinical Neuropsychologist | Friday, November 21, 2025 | Neuroscience

Nature Neuroscience, Published online: 21 November 2025; doi:10.1038/s41593-025-02115-wAstrocytes are associated with Alzheimer’s disease pathogenesis. We found that the transcription factor Sox9 functions to enhance astrocytic phagocytosis of Aβ plaques via MEGF10,...

Behavioral devaluation by local resistance to dopamine

by Clinical Neuropsychologist | Thursday, November 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 November 2025; doi:10.1038/s41593-025-02079-xThe dopamine motivating animals to perform a current behavior also desensitizes local D2 dopamine receptors. Dopamine signaling is less effective in subsequent rounds, resulting in...

Tau pathology in mouse spinal neurons underlies early touch loss and heralds cognitive decline

by Clinical Neuropsychologist | Thursday, November 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 November 2025; doi:10.1038/s41593-025-02138-3Early tactile deficits in patients with Alzheimer disease (AD) and AD mouse models map to tau pathology in spinal cholecystokinin (CCK) neurons. In AD mice, reducing tau or c-Maf...

Author Correction: Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity

by Clinical Neuropsychologist | Wednesday, November 19, 2025 | Neuroscience

Nature Neuroscience, Published online: 19 November 2025; doi:10.1038/s41593-025-02172-1Author Correction: Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity If you do not see content above, kindly GO TO SOURCE. Not all publishers...

Brain-wide analysis reveals movement encoding structured across and within brain areas

by Clinical Neuropsychologist | Tuesday, November 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 November 2025; doi:10.1038/s41593-025-02114-xUsing a large dataset of neural recordings and modern video-analysis methods, Wang, Kurgyis et al. describe a rich, structured encoding of movement across and within brain areas in...
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