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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration

by Clinical Neuropsychologist | Friday, March 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 March 2025; doi:10.1038/s41593-025-01914-5Targeting the endothelium across ages and neurodegenerative diseases in 92 donors with single-cell inCITE-seq reveals similar alterations in ~40% of capillaries in AD, ALS and FTD....

An axonal brake on striatal dopamine output by cholinergic interneurons

by Clinical Neuropsychologist | Thursday, March 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 March 2025; doi:10.1038/s41593-025-01906-5Cholinergic interneurons act at nicotinic receptors to depress dopamine release, interrupting its relationship to dopamine neuron firing and supporting an inverse scaling of dopamine...

Sympathetic and parasympathetic subtypes of body-first Lewy body disease observed in postmortem tissue from prediagnostic individuals

by Clinical Neuropsychologist | Thursday, March 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 March 2025; doi:10.1038/s41593-025-01910-9This postmortem study identifies brain-first and two body-first subtypes in prediagnostic cases of Lewy body disease. It highlights sympathetic and parasympathetic pathways in...

Expectation-driven sensory adaptations support enhanced acuity during categorical perception

by Clinical Neuropsychologist | Thursday, March 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 March 2025; doi:10.1038/s41593-025-01899-1Bayesian models explain how context biases perceptual behavior toward expected categories, but sensory neurons do not reflect this bias. Instead, expectation sharpens sensory acuity,...

Study-phase reinstatement predicts subsequent recall

by Clinical Neuropsychologist | Tuesday, March 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 March 2025; doi:10.1038/s41593-025-01884-8How can the brain improve memory for an experience after it has occurred? Halpern et al. use intracranial EEG to show that, even while processing current experiences, people reactivate...
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