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Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter

by Clinical Neuropsychologist | Monday, February 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 February 2025; doi:10.1038/s41593-025-01878-6White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in...

Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

by Clinical Neuropsychologist | Monday, February 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 February 2025; doi:10.1038/s41593-025-01882-wSocioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on...

PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors

by Clinical Neuropsychologist | Monday, February 24, 2025 | Neuroscience

Nature Neuroscience, Published online: 24 February 2025; doi:10.1038/s41593-024-01865-3The authors show PTEN mutations, which can cause both congenital hydrocephalus and autism spectrum disorder, disrupt CSF homeostasis and brain connectivity in mice. Reducing mTORC1...

Developmentally distinct architectures in top–down pathways controlling threat avoidance

by Clinical Neuropsychologist | Wednesday, February 19, 2025 | Neuroscience

Nature Neuroscience, Published online: 19 February 2025; doi:10.1038/s41593-025-01890-wThrough circuit dissection in juvenile, adolescent and adult mice, Klune, Goodpaster and colleagues reveal multiple developmental switches in mPFC–NAc and mPFC–BLA pathways that...

Viewing Different Views of the World Through a Scientific Lens

by Clinical Neuropsychologist | Wednesday, February 19, 2025 | Neuroscience

CNS 2025 Q&A with Emily Finn In today’s highly polarized society, most people can at least agree to the idea that any two individuals can view an event in vastly different ways. And those perceptions become our reality. But how can scientists study those...
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