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Oligodendrocytes in Alzheimer’s disease pathophysiology

by Clinical Neuropsychologist | Wednesday, January 29, 2025 | Neuroscience

Nature Neuroscience, Published online: 29 January 2025; doi:10.1038/s41593-025-01873-xEmerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression....

The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow

by Clinical Neuropsychologist | Tuesday, January 28, 2025 | Neuroscience

Nature Neuroscience, Published online: 28 January 2025; doi:10.1038/s41593-024-01868-0The default mode network (DMN) is implicated in cognition and behavior. Here, the authors show that the DMN is cytoarchitecturally heterogeneous, it contains regions receptive to...

Retrieval of conditioned immune response in male mice is mediated by an anterior–posterior insula circuit

by Clinical Neuropsychologist | Monday, January 27, 2025 | Neuroscience

Nature Neuroscience, Published online: 27 January 2025; doi:10.1038/s41593-024-01864-4The authors show that a bidirectional circuit connecting the anterior and posterior (aIC–pIC) insula mediates the conditioned immune response in male mice, illustrating a mechanism...

Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease

by Clinical Neuropsychologist | Thursday, January 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 January 2025; doi:10.1038/s41593-024-01866-2Yuan et al. find that the kidney can serve as a site of initiation for the spread of pathological α-synuclein to the brain, contributing to the development of Parkinson’s disease...

α-Synuclein deposition in the kidney may contribute to Parkinson’s disease

by Clinical Neuropsychologist | Thursday, January 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 January 2025; doi:10.1038/s41593-024-01867-1During the pathogenesis of Parkinson’s disease (PD), α-synuclein pathology may originate in peripheral organs and spread to the CNS. Using human tissue samples and multiple...
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