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In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

by Clinical Neuropsychologist | Tuesday, December 24, 2024 | Neuroscience

Nature Neuroscience, Published online: 24 December 2024; doi:10.1038/s41593-024-01829-7Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be...

Transsynaptic labeling and transcriptional control of zebrafish neural circuits

by Clinical Neuropsychologist | Thursday, December 19, 2024 | Neuroscience

Nature Neuroscience, Published online: 19 December 2024; doi:10.1038/s41593-024-01815-zThe trans-Tango genetic strategy, which mediates signaling across synapses, was adapted to identify neural connections in a vertebrate nervous system, with synaptic partners...

A single-cell mass cytometry-based atlas of the developing mouse brain

by Clinical Neuropsychologist | Wednesday, December 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 December 2024; doi:10.1038/s41593-024-01786-1In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based...

Creating a Blueprint for Sleep Engineering 

by Clinical Neuropsychologist | Wednesday, December 18, 2024 | Neuroscience

CNS 2025: Q&A with Ken Paller What started for Ken Paller as traditional memory research in cognitive neuroscience has now turned into an integrated approach to understanding memory, sleep, and dreams. In addition to using novel tools and technologies to modify...

Heat acclimation induces hypothalamic temperature sensitivity that promotes heat tolerance

by Clinical Neuropsychologist | Tuesday, December 17, 2024 | Neuroscience

Nature Neuroscience, Published online: 17 December 2024; doi:10.1038/s41593-024-01835-9After long-term heat exposure, a discrete group of hypothalamic neurons in the anterior ventromedial preoptic area become hyperactive and acquire temperature sensitivity. This...
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