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Leveraging Brain Connectivity to Control Unwanted Thoughts

by Clinical Neuropsychologist | Tuesday, January 7, 2025 | Neuroscience

CNS 2025: Q&A with Marie Banich Marie Banich’s journey in cognitive neuroscience started with very personal motivations: first from a curiosity about what her family’s propensity for left handedness meant and then to a drive to help people who suffer from unwanted...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01833-xMicroglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes...

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01847-5This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several...

NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01849-3Hehlert et al. report that the gating spring that pulls open mechanosensitive NOMPC channels is not their helical ankyrin tether, but instead an elastic hinge that suspends that...

Context-dependent decision-making in the primate hippocampal–prefrontal circuit

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01839-5The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value...
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