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Context-dependent decision-making in the primate hippocampal–prefrontal circuit

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01839-5The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value...

Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01850-wNguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA...

Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01848-4Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand...

Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors

by Clinical Neuropsychologist | Thursday, January 2, 2025 | Neuroscience

Nature Neuroscience, Published online: 02 January 2025; doi:10.1038/s41593-024-01807-zThis study shows that cerebellar Bergmann glia process noxious stimuli by integrating signals from the locus coeruleus. This mechanism modulates pain-related behaviors. These...

Neurocognitive dynamics of human cooperation unveiled by intracranial recordings

by Clinical Neuropsychologist | Thursday, January 2, 2025 | Neuroscience

Nature Neuroscience, Published online: 02 January 2025; doi:10.1038/s41593-024-01825-xSimultaneous intracranial electroencephalographic recordings from individuals playing a dynamic cooperation game reveal unique neural profiles of high-gamma intra-brain activity and...
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