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Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis

by Clinical Neuropsychologist | Monday, November 17, 2025 | Neuroscience

Nature Neuroscience, Published online: 17 November 2025; doi:10.1038/s41593-025-02100-3Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early...

Author Correction: Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape

by Clinical Neuropsychologist | Thursday, November 13, 2025 | Neuroscience

Nature Neuroscience, Published online: 13 November 2025; doi:10.1038/s41593-025-02170-3Author Correction: Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape If you do not see content above, kindly GO TO SOURCE....

Genetic targeting of premyelinating oligodendrocytes reveals activity-dependent myelination mechanisms

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02110-1A new in vivo genetic tool allows labeling, tracing and manipulation of premyelinating oligodendrocytes, enabling further investigations of this transient cell stage during...

A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02090-2Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations. The...

Estrogen modulates reward prediction errors and reinforcement learning

by Clinical Neuropsychologist | Tuesday, November 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02104-zDopamine encoding of reward prediction errors naturally fluctuates over females’ reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake...
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