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Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences

by Clinical Neuropsychologist Online | Monday, November 3, 2025 | Neuroscience

Nature Neuroscience, Published online: 03 November 2025; doi:10.1038/s41593-025-02099-7Dominant coactivation patterns are primarily studied in resting-state fMRI. Here, the authors study the rest of the signal, which reveals ‘caricatured’ connectomes with improved...

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD

by Clinical Neuropsychologist Online | Friday, October 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 October 2025; doi:10.1038/s41593-025-02096-wTDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment...

Specialized structure of neural population codes in parietal cortex outputs

by Clinical Neuropsychologist Online | Friday, October 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 October 2025; doi:10.1038/s41593-025-02095-xCortical neurons comprising an output pathway form a specialized population code that enhances the propagation of information to a downstream target, potentially improving the...

Dendritome mapping reveals the spatial organization of striatal neuron morphology

by Clinical Neuropsychologist Online | Friday, October 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 October 2025; doi:10.1038/s41593-025-02085-zThe authors mapped the dendritic morphology of thousands of striatal D1-type and D2-type medium spiny neurons in healthy and Huntington’s disease mouse brains, revealing dendritic...

Laser-engineered PRIME fiber for panoramic reconfigurable control of neural activity

by Clinical Neuropsychologist Online | Friday, October 31, 2025 | Neuroscience

Nature Neuroscience, Published online: 31 October 2025; doi:10.1038/s41593-025-02106-xThe authors develop a neural probe with over 1,000 light emitters arranged along its length and circumference, enabling panoramic 3D optical stimulation across large brain volumes....
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