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Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01850-wNguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA...

Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01848-4Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand...

Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors

by Clinical Neuropsychologist | Thursday, January 2, 2025 | Neuroscience

Nature Neuroscience, Published online: 02 January 2025; doi:10.1038/s41593-024-01807-zThis study shows that cerebellar Bergmann glia process noxious stimuli by integrating signals from the locus coeruleus. This mechanism modulates pain-related behaviors. These...

Neurocognitive dynamics of human cooperation unveiled by intracranial recordings

by Clinical Neuropsychologist | Thursday, January 2, 2025 | Neuroscience

Nature Neuroscience, Published online: 02 January 2025; doi:10.1038/s41593-024-01825-xSimultaneous intracranial electroencephalographic recordings from individuals playing a dynamic cooperation game reveal unique neural profiles of high-gamma intra-brain activity and...

Negative self-experiences shape responses to others’ emotional states

by Clinical Neuropsychologist | Thursday, January 2, 2025 | Neuroscience

Nature Neuroscience, Published online: 02 January 2025; doi:10.1038/s41593-024-01817-xMice react differently to others’ stress depending on their own past experience of the same (but not different) stress. Corticotropin-releasing factor (CRF) neuron activity in the...
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