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Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle

by Clinical Neuropsychologist | Monday, November 25, 2024 | Neuroscience

Nature Neuroscience, Published online: 25 November 2024; doi:10.1038/s41593-024-01822-0Lüthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep. Stressful...

Embracing Teens as Strategic Risk-Takers

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

CNS 2025: Q&A with Adriana Galván As a parent of a teen, it can be crushingly difficult to sort through the social drama while attempting to provide guidance that you hope will keep your teen safe. Cognitive neuroscientists are finding, however, that the...

Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01808-yThe Rett syndrome protein MeCP2 regulates gene transcription by binding to methylated DNA. Here the authors find that MeCP2 also regulates key neuronal genes by binding to...

Predicting modular functions and neural coding of behavior from a synaptic wiring diagram

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01784-3The authors determine the synaptic wiring diagram of a vertebrate circuit and reveal behaviorally associated modules. A model based on this connectome predicts neural coding and...

The BRAIN initiative: a pioneering program on the precipice

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01811-3Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric...
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