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Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer’s disease

by Clinical Neuropsychologist Online | Saturday, February 24, 2024 | Dementia

Abstract INTRODUCTION Increasing evidence suggests that amyloid reduction could serve as a plausible surrogate endpoint for clinical and cognitive efficacy. The double-blind phase 3 DIAN-TU-001 trial tested clinical and cognitive declines with increasing doses of...

Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change

by Clinical Neuropsychologist Online | Saturday, February 24, 2024 | Dementia

Abstract INTRODUCTION Individuals in socioeconomically disadvantaged neighborhoods exhibit increased risk for impaired cognitive function. Whether this association relates to the major dementia-related neuropathologies is unknown. METHODS This cross-sectional study...

Patient‐ and proxy‐reported quality of life in advanced dementia with Lewy bodies

by Clinical Neuropsychologist Online | Saturday, February 24, 2024 | Dementia

Abstract INTRODUCTION Little is known regarding quality of life (QoL) in dementia with Lewy bodies (DLB), particularly in advanced stages. METHODS Dyads of individuals with moderate–advanced DLB and their primary caregivers were recruited from specialty clinics,...

Cognitive and behavioural rehabilitation interventions for survivors of childhood cancer with neurocognitive sequelae: A systematic review

by Clinical Neuropsychologist Online | Friday, February 23, 2024 | Neurorehabilitation

Volume 35, Issue 1, January 2025, Page 131-158. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Kaja Solland Egset Magnhild Eitrem Røkke Trude Reinfjell...

Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories

by Clinical Neuropsychologist Online | Friday, February 23, 2024 | Neuroscience

Nature Neuroscience, Published online: 23 February 2024; doi:10.1038/s41593-024-01586-7Sias et al. show that dopamine projections to the basolateral amygdala drive the reward learning that supports the predictions and inferences needed for adaptive decision-making. If...
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