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Identification of a cold sensor in peripheral somatosensory neurons

by Clinical Neuropsychologist Online | Monday, March 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 March 2024; doi:10.1038/s41593-024-01606-6Cold sensor identities in peripheral somatosensory neurons remain obscure. We show that GluK2, a kainate-type glutamate-sensing chemoreceptor that mediates synaptic transmission in the...

The kainate receptor GluK2 mediates cold sensing in mice

by Clinical Neuropsychologist Online | Monday, March 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 March 2024; doi:10.1038/s41593-024-01585-8The identity of receptors sensing cold temperatures in peripheral somatosensory neurons remains obscure. Cai et al. report that GluK2, a kainate receptor mediating synaptic...

Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics

by Clinical Neuropsychologist Online | Monday, March 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 March 2024; doi:10.1038/s41593-024-01595-6A real-time analysis system was developed for an up to 500-megabyte-per-second image stream. This system can extract activities from up to 100,000 neurons in larval zebrafish brains...

Rural‐urban disparities in the diagnosis and treatment of hypertension and diabetes among aging Indians

by Clinical Neuropsychologist Online | Sunday, March 10, 2024 | Dementia

Abstract INTRODUCTION Hypertension and diabetes are modifiable risk factors for dementia. We aimed to assess rural-urban disparities in the diagnosis and treatment of these conditions among aging Indians. METHODS Participants (n = 6316) were from two parallel,...

Genetic associations with dementia‐related proteinopathy: Application of item response theory

by Clinical Neuropsychologist Online | Sunday, March 10, 2024 | Dementia

Abstract INTRODUCTION Although dementia-related proteinopathy has a strong negative impact on public health, and is highly heritable, understanding of the related genetic architecture is incomplete. METHODS We applied multidimensional generalized partial credit...
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