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PKCδ serves as a potential biomarker and therapeutic target for microglia‐mediated neuroinflammation in Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, June 28, 2024 | Dementia

Abstract INTRODUCTION To investigate the role of a novel type of protein kinase C delta (PKCδ) in the neuroinflammation of Alzheimer’s disease (AD). METHODS We analyzed PKCδ and inflammatory cytokines levels in cerebrospinal fluid (CSF) of AD and normal...

Age-stratified norms for Raven’s standard progressive matrices for Sri Lankan adults

by Clinical Neuropsychologist Online | Friday, June 28, 2024 | Neuropsychology (general)

Volume 39, Issue 1, January 2025, Page 203-217. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Tharaka L. Dassanayake Dewasmika I. Ariyasinghe Anuradha...

Alzheimer’s disease biomarker burden in primary motor cortices is associated with poorer dexterity performance

by Clinical Neuropsychologist Online | Thursday, June 27, 2024 | Dementia

Abstract INTRODUCTION Motor function has correlated with longevity and functionality; however, there is limited research on those with Alzheimer’s disease (AD). We studied the association between motor functionality and AD pathology in primary motor and medial...

Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndrome

by Clinical Neuropsychologist Online | Thursday, June 27, 2024 | Dementia

Abstract INTRODUCTION Cognitive impairment is a core feature of Down syndrome (DS), and the underlying neurobiological mechanisms remain unclear. Translation dysregulation is linked to multiple neurological disorders characterized by cognitive impairments....

Using a nonparametric item response theory model to identify patterns of cognitive decline: The Mokken scale analysis

by Clinical Neuropsychologist Online | Thursday, June 27, 2024 | Neuropsychology (general)

Abstract Cognitive decline, particularly in dementia, presents complex challenges in early detection and diagnosis. While Item Response Theory (IRT) has been instrumental in identifying patterns of cognitive impairment through psychometric tests, its parametric models...
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