by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Dementia
Abstract INTRODUCTION The long-term implications of disclosing Alzheimer’s disease (AD) biomarker information to cognitively unimpaired individuals are unknown. METHODS We compared participants who disclosed their elevated amyloid imaging result in a preclinical...
by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Dementia
Abstract INTRODUCTION Early symptoms in young onset Alzheimer’s disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population-based study aimed to map adverse occupational events preceding YOAD diagnosis as potential prodromal signs. METHODS...
by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Dementia
Abstract INTRODUCTION We investigated the moderating effects of midlife and late-life cognitive activity (CA) on the relationship between tau pathology and both cognition and cognitive decline. METHODS Eighty-nine non-demented older adults from a Korean cohort...
by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 February 2025; doi:10.1038/s41593-024-01865-3The authors show PTEN mutations, which can cause both congenital hydrocephalus and autism spectrum disorder, disrupt CSF homeostasis and brain connectivity in mice. Reducing mTORC1...
by Clinical Neuropsychologist Online | Monday, February 24, 2025 | Neuroscience
Nature Neuroscience, Published online: 24 February 2025; doi:10.1038/s41593-025-01882-wSocioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on...
