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Bone marrow myelopoiesis dysfunction in Alzheimer’s disease limits monocyte homing to the brain and drives disease progression

by Clinical Neuropsychologist Online | Tuesday, September 8, 2026 | Neuroscience

Nature Neuroscience, Published online: 08 September 2026; doi:10.1038/s41593-026-02417-7Alzheimer’s disease progression involves reduced bone marrow production of myeloid cells due to type I interferon signaling, which hampers the homing of protective immune cells to...

Intestinal infections establish antigen-specific, long-lived memory CD4+ T cells in the brain and meninges

by Clinical Neuropsychologist Online | Tuesday, September 8, 2026 | Neuroscience

Nature Neuroscience, Published online: 08 September 2026; doi:10.1038/s41593-026-02428-4Intestinal CD4+ T cells migrate to the dura and brain following gut infection with bacteria or parasites, establishing a long-lived memory population capable of proliferation and...

The hidden role of the bone marrow in Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, September 8, 2026 | Neuroscience

Nature Neuroscience, Published online: 08 September 2026; doi:10.1038/s41593-026-02418-6Although Alzheimer’s disease (AD) is a disease of the brain, we demonstrate that it disrupts myeloid cell production in the bone marrow via a type I interferon signal, preventing...

The Cog‐Aging: a 15‐year cohort study of cognition in Brazilian older adults

by Clinical Neuropsychologist Online | Monday, September 7, 2026 | Dementia

Abstract BACKGROUND Prevalence of dementia is higher in low- and middle-income countries (LMICs). However, longitudinal studies characterizing cognitive decline and its clinical and epidemiological predictors remain scarce in Brazil. METHODS Participants were enrolled...

Distinct ocular microvascular alterations in Alzheimer’s disease and cerebral small vessel disease

by Clinical Neuropsychologist Online | Monday, September 7, 2026 | Dementia

Abstract INTRODUCTION While both Alzheimer’s disease (AD) and cerebral small vessel disease (CSVD) involve vascular dysfunction, the ocular microvascular differences between them remain largely underinvestigated. METHODS This cross-sectional study included 650...
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