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Middle Cerebral Artery M2 Occlusions: Impact of Segment Dominance and Benefit of Direct Aspiration for the First‐Pass Effect

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroimaging

ABSTRACT Background and Purpose Endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) with M2 segment occlusion of the middle cerebral artery (MCA) is debatable. This study assessed the efficacy, safety, and functional outcomes of EVT in M2 occlusion...

Functional Connectivity to the Amygdala in the Neonate Is Impacted by the Maternal Anxiety Level During Pregnancy

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroimaging

ABSTRACT Background and Purpose Anxiety during pregnancy is common, and exposure to heightened anxiety during pregnancy may influence children’s brain development and functioning. However, it is unclear if exposure to low levels of anxiety in utero would also...

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01833-xMicroglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes...

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01847-5This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several...

NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01849-3Hehlert et al. report that the gating spring that pulls open mechanosensitive NOMPC channels is not their helical ankyrin tether, but instead an elastic hinge that suspends that...
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