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Context-dependent decision-making in the primate hippocampal–prefrontal circuit

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01839-5The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value...

Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01850-wNguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA...

Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus

by Clinical Neuropsychologist Online | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01848-4Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand...

MetaRehabVerse: The Great Opportunity to Put the Person’s Functioning and Participation at the Center of Healthcare

by Clinical Neuropsychologist Online | Saturday, January 4, 2025 | Neurorehabilitation

Neurorehabilitation and Neural Repair, Volume 39, Issue 3, Page 241-255, March 2025. Background and Objective:The metaverse refers to a digital realm accessible via internet connections using virtual reality and augmented reality glasses for promoting a new era of...

How gut bacteria influence the brain barriers, neuroinflammation and Alzheimer’s disease: a role for bacterial metabolites and extracellular vesicles

by Clinical Neuropsychologist Online | Friday, January 3, 2025 | Dementia

Abstract Background The brain is shielded from the peripheral circulation by central nervous system (CNS) barriers, comprising the well-known blood-brain barrier (BBB) and the less recognized blood-cerebrospinal fluid (CSF) barrier located within the brain ventricles....
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