by Clinical Neuropsychologist Online | Friday, November 22, 2024 | Dementia
Abstract INTRODUCTION In the research setting, obtaining accurate established biomarker measurements and maximizing use of the precious samples is key. Accurate technologies are available for Alzheimer’s disease (AD), but no platform can measure all the...
by Clinical Neuropsychologist Online | Friday, November 22, 2024 | Dementia
Abstract BACKGROUND This study examines whether phosphorylated plasma Tau217 ratio (pTau217R) can predict tau accumulation in different brain regions, as measured by positron emission tomography (PET) standardized uptake value ratio (SUVR), for staging...
by Clinical Neuropsychologist Online | Friday, November 22, 2024 | Dementia
Abstract INTRODUCTION While the role of apolipoprotein E (APOE) ε4 in Alzheimer’s disease (AD) susceptibility has been studied extensively, much less is known about the differences in disease presentation in APOE ε4 carriers versus non-carriers. METHODS To help...
by Clinical Neuropsychologist Online | Friday, November 22, 2024 | Neuroscience
Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01808-yThe Rett syndrome protein MeCP2 regulates gene transcription by binding to methylated DNA. Here the authors find that MeCP2 also regulates key neuronal genes by binding to...
by Clinical Neuropsychologist Online | Friday, November 22, 2024 | Neuroscience
Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01784-3The authors determine the synaptic wiring diagram of a vertebrate circuit and reveal behaviorally associated modules. A model based on this connectome predicts neural coding and...
