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The BRAIN initiative: a pioneering program on the precipice

by Clinical Neuropsychologist Online | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01811-3Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric...

Biological validation of peak‐width of skeletonized mean diffusivity as a VCID biomarker: The MarkVCID Consortium

by Clinical Neuropsychologist Online | Thursday, November 21, 2024 | Dementia

Abstract BACKGROUND Peak-width of skeletonized mean diffusivity (PSMD), a neuroimaging marker of cerebral small vessel disease (SVD), has shown excellent instrumental properties. Here, we extend our work to perform a biological validation of PSMD. METHODS We included...

476. Why I Hate “Brief” Evals

by Clinical Neuropsychologist Online | Thursday, November 21, 2024 | Neuro Podcasts

Would you rather read the transcript? Click here. I talk to a lot of folks during my consulting meetings and coaching groups who are interested in offering an evaluation “menu” in their testing practices. Typically this takes the form of “brief” evaluations answering...

The cell-type underpinnings of the human functional cortical connectome

by Clinical Neuropsychologist Online | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01812-2Here Zhang et al. establish multiscale relationships that link postmortem cell-type distributions with the in vivo functional organization of the human cerebral cortex, as assessed...

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01801-5Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s...
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