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Dissecting the epigenetic regulation of human brain organoid development in single cells

by Clinical Neuropsychologist Online | Tuesday, June 25, 2024 | Neuroscience

Nature Neuroscience, Published online: 25 June 2024; doi:10.1038/s41593-024-01653-zWe present a developmental atlas that offers insight into sequential epigenetic changes underlying early human brain development modeled in organoids, which reconstructs the...

Correction to “CALHM2 V136G polymorphism reduces astrocytic ATP release and is associated with depressive symptoms and Alzheimer’s disease risk”

by Clinical Neuropsychologist Online | Monday, June 24, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: | June 24, 2024 Wiley: Alzheimer’s & Dementia: Table...

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

by Clinical Neuropsychologist Online | Monday, June 24, 2024 | Neuroscience

Nature Neuroscience, Published online: 24 June 2024; doi:10.1038/s41593-024-01652-0The mechanisms underlying human cell diversity are unclear. Here the authors provide a single-cell epigenome map of human neural organoid development and dissect how epigenetic changes...

A high-density 1,024-channel probe for brain-wide recordings in non-human primates

by Clinical Neuropsychologist Online | Monday, June 24, 2024 | Neuroscience

Nature Neuroscience, Published online: 24 June 2024; doi:10.1038/s41593-024-01692-6A probe incorporating 1,024 simultaneously recorded channels with shank length up to 90 mm exhibits high chronic recording stability and enables brain-wide large-scale neural population...

In vivo detection of Alzheimer’s and Lewy body disease concurrence: Clinical implications and future perspectives

by Clinical Neuropsychologist Online | Saturday, June 22, 2024 | Dementia

Abstract INTRODUCTION The recent introduction of seed amplification assays (SAAs) detecting misfolded α-synuclein, a pathology-specific marker for Lewy body disease (LBD), has allowed the in vivo identification and phenotypic characterization of patients with...
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