by Clinical Neuropsychologist | Wednesday, March 20, 2024 | Dementia
Abstract BACKGROUND Variants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer’s disease (LOAD). METHODS CRISPR-Cas9 was used to generate an Abca7V1613M variant in mice, modeling...
by Clinical Neuropsychologist | Wednesday, March 20, 2024 | Dementia
Abstract INTRODUCTION The Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is...
by Clinical Neuropsychologist | Wednesday, March 20, 2024 | Dementia
Abstract INTRODUCTION The Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is...
by Clinical Neuropsychologist | Wednesday, March 20, 2024 | Dementia
Abstract INTRODUCTION People with Down syndrome (DS) have high risk of developing Alzheimer’s disease (AD). This study examined mean ages of AD diagnosis and associations with co-occurring conditions among adults with DS from five European countries. METHODS...
by Clinical Neuropsychologist | Wednesday, March 20, 2024 | Dementia
Abstract INTRODUCTION Distance to physicians may explain some of the disparities in Alzheimer’s disease and related dementia (AD/ADRD) outcomes. METHODS We generated round trip distance between residences of decedents with AD/ADRD and the nearest neurologist and...
by Clinical Neuropsychologist | Tuesday, March 19, 2024 | Dementia
Abstract INTRODUCTION Although glymphatic function is involved in Alzheimer’s disease (AD), its potential for predicting the pathological and clinical progression of AD and its sequential association with core AD biomarkers is poorly understood. METHODS...