Fibrillar tau alters cerebral endothelial cell metabolism, vascular inflammatory activation, and barrier function in vitro and in vivo

by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia

Abstract INTRODUCTION The presence of tau aggregates in and around the brain vasculature in Alzheimer’s disease (AD) and tauopathies suggests its possible pathogenicity to cerebral endothelial cells (ECs). METHODS We used an in vitro model of the blood–brain...

Rethinking biological biomarkers to track treatment efficacy in Alzheimer’s disease: Focus on brain connectivity

by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia

Alzheimer’s &Dementia, Volume 21, Issue 3, March 2025. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Lorenzo Pini, Bruno P Imbimbo | March 20,...

Social determinants of health and risk of dementia among older men and women: A 12‐year cohort study in Australia

by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia

Abstract INTRODUCTION Social determinants of health (SDH) are recognized as contributing factors to cognitive disorders, but their collective influence on dementia risk remains unclear. METHODS A gender-disaggregated analysis was conducted on 12,896 community-dwelling...

Marital status and risk of dementia over 18 years: Surprising findings from the National Alzheimer’s Coordinating Center

by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia

Abstract INTRODUCTION Marital status is a potential risk/protective factor for adverse health outcomes. This study tested whether marital status was associated with dementia risk in older adults. METHODS Participants (N = 24,107; Meanage = 71.79) were from the...

Metabolic stress and age drive inflammation and cognitive decline in mice and humans

by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia

Abstract INTRODUCTION Metabolic stressors (obesity, metabolic syndrome, prediabetes, and type 2 diabetes [T2D]) increase the risk of cognitive impairment (CI), including Alzheimer’s disease (AD). Immune system dysregulation and inflammation, particularly...

Connectome‐based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer’s disease

by Clinical Neuropsychologist | Thursday, March 20, 2025 | Dementia

Abstract INTRODUCTION Autosomal dominant Alzheimer’s disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed...