Experimental laboratory models as tools for understanding modifiable dementia risk

by Clinical Neuropsychologist | Tuesday, April 30, 2024 | Dementia

Abstract Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to...

Data‐driven decomposition and staging of flortaucipir uptake in Alzheimer’s disease

by Clinical Neuropsychologist | Tuesday, April 30, 2024 | Dementia

Abstract INTRODUCTION Previous approaches pursuing in vivo staging of tau pathology in Alzheimer’s disease (AD) have typically relied on neuropathologically defined criteria. In using predefined systems, these studies may miss spatial deposition patterns which...

Metabolomics profiling reveals distinct, sex‐specific signatures in serum and brain metabolomes in mouse models of Alzheimer’s disease

by Clinical Neuropsychologist | Sunday, April 28, 2024 | Dementia

Abstract INTRODUCTION Increasing evidence suggests that metabolic impairments contribute to early Alzheimer’s disease (AD) mechanisms and subsequent dementia. Signals in metabolic pathways conserved across species can facilitate translation. METHODS We...

Failure of the glymphatic system as possible link between lumbar spinal stenosis and dementia

by Clinical Neuropsychologist | Saturday, April 27, 2024 | Dementia

Alzheimer’s &Dementia, EarlyView. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: Pasquale Gallina, Francesco Lolli, Berardino Porfirio | April...

Atrophy links lower novelty‐related locus coeruleus connectivity to cognitive decline in preclinical AD

by Clinical Neuropsychologist | Saturday, April 27, 2024 | Dementia

Abstract INTRODUCTION Animal research has shown that tau pathology in the locus coeruleus (LC) is associated with reduced norepinephrine signaling, lower projection density to the medial temporal lobe (MTL), atrophy, and cognitive impairment. We investigated the...

Echocardiographic measures of the left heart and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: The CABLE study

by Clinical Neuropsychologist | Saturday, April 27, 2024 | Dementia

Abstract INTRODUCTION This study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer’s disease (AD) biomarkers, and cognition. METHODS Multiple linear regressions were conducted in 1244...