Results from the long‐term extension of PRIME: A randomized Phase 1b trial of aducanumab

by Clinical Neuropsychologist Online | Wednesday, April 3, 2024 | Dementia

Abstract INTRODUCTION Aducanumab selectively targets aggregated forms of amyloid beta (Aβ), a neuropathological hallmark of Alzheimer’s disease (AD). METHODS PRIME was a Phase 1b, double-blind, randomized clinical trial of aducanumab. During the 12-month...

On the effect heterogeneity of established disease susceptibility loci for Alzheimer’s disease across different genetic ancestries

by Clinical Neuropsychologist Online | Tuesday, April 2, 2024 | Dementia

Abstract INTRODUCTION Genome-wide association studies have identified numerous disease susceptibility loci (DSLs) for Alzheimer’s disease (AD). However, only a limited number of studies have investigated the dependence of the genetic effect size of established...

Structural white matter properties and cognitive resilience to tau pathology

by Clinical Neuropsychologist Online | Tuesday, April 2, 2024 | Dementia

Abstract INTRODUCTION We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer’s disease pathology years prior to clinical onset. METHODS We examined whether global efficiency, an indicator...

Antidepressant use in relation to dementia risk, cognitive decline, and brain atrophy

by Clinical Neuropsychologist Online | Tuesday, April 2, 2024 | Dementia

Abstract INTRODUCTION We aimed to assess the effect of antidepressant use on dementia risk, cognitive decline, and brain atrophy. METHODS In this prospective cohort study, we included 5511 dementia-free participants (Mini-Mental State Examination [MMSE] > 25) of...

Minimal clinically important difference in Alzheimer’s disease: Rapid review

by Clinical Neuropsychologist Online | Tuesday, April 2, 2024 | Dementia

Abstract INTRODUCTION We conducted a rapid systematic review of minimal clinically important differences (MCIDs) for Alzheimer’s disease (AD) trial endpoints. METHODS Two reviewers searched EMBASE, MEDLINE, and PubMed from inception to June 4, 2023. RESULTS Ten...

Early‐onset dementia and risk of hip fracture and major osteoporotic fractures

by Clinical Neuropsychologist Online | Tuesday, April 2, 2024 | Dementia

Abstract INTRODUCTION There is limited knowledge about early-onset dementia (EOD) on fracture risk. METHODS Individuals ages 50 to 64 were identified from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (2012 to 2019). The...