by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia
Abstract INTRODUCTION We investigated the association of neighborhood disadvantage with the incidence of Alzheimer’s disease and related dementias (ADRD) in the longitudinal Black Women’s Health Study (BWHS). METHODS The study included 10,915 BWHS...
by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia
Abstract INTRODUCTION We explored patients’ and families’ interest in, predictors of, and considerations regarding genetic testing for monogenic causes of dementia in a diagnostic setting. METHODS This mixed-methods study evaluated 519 consecutive Alzheimer Center...
by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia
Abstract INTRODUCTION Numerous studies on Alzheimer’s disease polygenic risk scores (PRSs) overlook sample overlap between International Genomics of Alzheimer’s Project (IGAP) and target datasets like Alzheimer’s Disease Neuroimaging Initiative...
by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia
Abstract INTRODUCTION The entorhinal cortex (ERC) and perforant path (PP) fibers are critical structures in the pathology of Alzheimer’s disease (AD). This study aims to explore these regions using high-field magnetic resonance imaging (MRI), with the goal of...
by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia
Abstract INTRODUCTION Neighborhood-level socioeconomic status (nSES) is associated with risk for cognitive impairment, but prior studies assessed nSES within an individual’s own residential area without considering the distribution of nSES among adjacent areas....
by Clinical Neuropsychologist | Monday, April 7, 2025 | Dementia
Abstract BACKGROUND Adults with Down syndrome (DS) have increased risk of Alzheimer’s disease (AD). The cholinergic system declines in AD, underlying many cognitive deficits. We investigated the relationship between amyloid accumulation and cholinergic terminal...
