Plasma eMTBR‐tau243 as a disease biomarker across Alzheimer’s disease clinical phenotypes

by Clinical Neuropsychologist Online | Friday, October 9, 2026 | Dementia

Abstract INTRODUCTION The concentration of endogenous tau microtubule-binding region containing residue-243 in plasma (eMTBR-tau243) has been proposed to be a sensitive biomarker of tangle pathology in Alzheimer’s disease (AD). We assessed eMTBR-tau243 and...

Proteomic dysregulation associated with cerebral amyloid angiopathy

by Clinical Neuropsychologist Online | Friday, October 9, 2026 | Dementia

Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is characterized by impaired vascular amyloid-β clearance, distinct from Alzheimer’s disease (AD), underscoring the need to clarify its molecular basis for predicting therapy-related amyloid-related imaging...

Diffusion MRI reveals amyloid plaque–associated cellular signatures through spatial transcriptomic integration

by Clinical Neuropsychologist Online | Friday, October 9, 2026 | Dementia

Abstract INTRODUCTION Amyloid plaque deposition is a defining feature of Alzheimer’s disease (AD), yet how plaque-associated cellular alterations are reflected in noninvasive imaging remains unclear. METHODS We integrated high-resolution diffusion magnetic...

Association between early‐life farming exposure and Alzheimer’s disease neuropathological burden

by Clinical Neuropsychologist Online | Friday, October 9, 2026 | Dementia

Abstract BACKGROUND Farming populations may face a disproportionate share of adverse exposures influencing Alzheimer’s disease (AD), yet farming data are rarely connected to cohorts with characterized AD neuropathology. Whether early-life exposure is related to...

Social Determinants of Health (SDOH) and Cognition: A Scoping Review

by Clinical Neuropsychologist Online | Thursday, October 8, 2026 | Dementia

Dementia, Ahead of Print. To map the evidence of disparities in cognition across different social determinants of health (SDOH), examine how SDOH are measured in the context of research on cognitive outcomes and identify knowledge gaps. PubMed, the Cochrane Library,...

Network‐dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, October 8, 2026 | Dementia

Abstract BACKGROUND Tau pathology in Alzheimer’s disease (AD) propagates along the brain’s connectome, yet the mechanisms by which tau drives neuronal dysfunction remain unclear. We hypothesized that dysfunction primarily emerges in regions close to...