Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans

by Clinical Neuropsychologist Online | Thursday, February 22, 2024 | Dementia

Abstract INTRODUCTION We investigated whether retinal capillary perfusion is a biomarker of cerebral small vessel disease and impaired cognition among Black Americans, an understudied group at higher risk for dementia. METHODS We enrolled 96 Black Americans without...

Mid‐life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late‐life subjective cognitive complaints in women

by Clinical Neuropsychologist Online | Thursday, February 22, 2024 | Dementia

Abstract INTRODUCTION Evidence is limited on the role of mid-life Dietary Approaches to Stop Hypertension (DASH) diet in late-life subjective cognitive complaints (SCCs). METHODS We included 5116 women (mean age in 1985–1991: 46 years) from the New York University...

Data‐driven lifestyle patterns and risk of dementia in older Australian women

by Clinical Neuropsychologist Online | Thursday, February 22, 2024 | Dementia

Abstract INTRODUCTION Many lifestyle factors have been associated with dementia, but there is limited evidence of how these group together. The aim of this study was to examine the clustering of lifestyle behaviors and associations with dementia. METHODS This...

sPDGFRβ and neuroinflammation are associated with AD biomarkers and differ by race: The ASCEND Study

by Clinical Neuropsychologist Online | Thursday, February 22, 2024 | Dementia

Abstract INTRODUCTION There remains an urgent need to identify preclinical pathophysiological mechanisms of Alzheimer’s disease (AD) development in high-risk, racially diverse populations. We explored the relationship between cerebrospinal fluid (CSF) markers of...

APOE Christchurch‐mimetic therapeutic antibody reduces APOE‐mediated toxicity and tau phosphorylation

by Clinical Neuropsychologist Online | Thursday, February 22, 2024 | Dementia

Abstract INTRODUCTION We discovered that the APOE3 Christchurch (APOE3Ch) variant may provide resistance to Alzheimer’s disease (AD). This resistance may be due to reduced pathological interactions between ApoE3Ch and heparan sulfate proteoglycans (HSPGs)....

Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER)

by Clinical Neuropsychologist Online | Thursday, February 22, 2024 | Dementia

Abstract INTRODUCTION The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)...