The Bayesian approach for real‐world implementation of plasma p‐tau217 in tertiary care memory clinics in Thailand

by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Dementia

Abstract INTRODUCTION Plasma phosphorylated tau (p-tau)217 is a promising biomarker for Alzheimer’s disease (AD) diagnosis, but its clinical implementation remains challenging. We propose a strategy based on Bayes’ theorem and test it in real-life memory...

Care partner‐informed meaningful change thresholds for the Clinical Dementia Rating‐Sum of Boxes for trials of early Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Dementia

Abstract INTRODUCTION Consensus definitions of meaningful within-patient change (MWPC) on the Clinical Dementia Rating-Sum of Boxes (CDR-SB) are needed. Existing estimates use clinician-rated anchors in clinically diagnosed Alzheimer’s disease (AD) populations....

Suppressing UBE2N ameliorates Alzheimer’s disease pathology through the clearance of amyloid beta

by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Dementia

Abstract INTRODUCTION Aging is one of the risk factors for the early onset of Alzheimer’s disease (AD). We previously discovered that the age-dependent increase in Ubiquitin Conjugating Enzyme E2 N (UBE2N) plays a role in the accumulation of misfolded proteins...

Prospects and challenges in using neuronal extracellular vesicles in biomarker research

by Clinical Neuropsychologist Online | Tuesday, July 16, 2024 | Dementia

Abstract Extracellular vesicles (EVs) hold promise as a source of disease biomarkers. The diverse molecular cargo of EVs can potentially indicate the status of their tissue of origin, even against the complex background of whole plasma. The main tools currently...

Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer’s disease continuum

by Clinical Neuropsychologist Online | Saturday, July 13, 2024 | Dementia

Abstract INTRODUCTION Despite parallel research indicating amyloid-β accumulation, alterations in cortical neurophysiological signaling, and multi-system neurotransmitter disruptions in Alzheimer’s disease (AD), the relationships between these phenomena remains...

Assessing cognitive impairment and disability in older adults through the lens of whole brain white matter patterns

by Clinical Neuropsychologist Online | Saturday, July 13, 2024 | Dementia

Abstract INTRODUCTION This study aimed to explore the potential of whole brain white matter patterns as novel neuroimaging biomarkers for assessing cognitive impairment and disability in older adults. METHODS We conducted an in-depth analysis of magnetic resonance...