by Clinical Neuropsychologist Online | Saturday, July 20, 2024 | Dementia
Abstract INTRODUCTION The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer’s disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also...
by Clinical Neuropsychologist Online | Friday, July 19, 2024 | Dementia
Abstract INTRODUCTION We aimed to evaluate clinical interpretation cutpoints for two plasma phosphorylated tau (p-tau)217 assays (ALZpath and Lumipulse) as predictors of amyloid status for implementation in clinical practice. METHODS Clinical performance of plasma...
by Clinical Neuropsychologist Online | Thursday, July 18, 2024 | Dementia
Abstract INTRODUCTION Risk prediction models aim to identify those at high risk to receive targeted interventions. We aimed to identify the proportion of future dementia cases that would be missed by a high-risk screening program. METHODS We identified validated...
by Clinical Neuropsychologist Online | Thursday, July 18, 2024 | Dementia
Abstract Currently there is a crisis in the long-term care workforce, as many workers experience poor pay, a lack of training, burnout, low quality working conditions, and physical strain, which is leading to a workforce shortage. To address this, the...
by Clinical Neuropsychologist Online | Thursday, July 18, 2024 | Dementia
Abstract INTRODUCTION Alzheimer’s disease (AD) is a devastating neurological disease with complex genetic etiology. Yet most known loci have only identified from the late-onset type AD in populations of European ancestry. METHODS We performed a two-stage...
by Clinical Neuropsychologist Online | Wednesday, July 17, 2024 | Dementia
Abstract INTRODUCTION Physical frailty is reversible, but little is known about the sustainability of frailty remission and its impact on dementia. METHODS Data were derived from the National Health and Aging Trends Study (NHATS) (2011 to 2021). Physical frailty was...
