Estimated effects of amyloid reduction on cognitive change: A Bayesian update across a range of priors

by Clinical Neuropsychologist Online | Thursday, February 22, 2024 | Dementia

Abstract INTRODUCTION The results of the CLARITY-AD, GRADUATE I and II, and TRAILBLAZER-ALZ 2 trials have rekindled discussion on the impact of amyloid-targeting drugs. We use a Bayesian approach to quantify how rational observers would have updated their prior...

An ethnography of mealtime care for people living with dementia in care homes

by Clinical Neuropsychologist Online | Wednesday, February 21, 2024 | Dementia

Dementia, Volume 23, Issue 6, Page 907-926, August 2024. Many people living with dementia have difficulties at mealtimes, which can result in serious complications for physical and mental health, leading to hospital admissions and even death. However, current training...

Protective effect of bilingualism on aging, MCI, and dementia: A community‐based study

by Clinical Neuropsychologist Online | Tuesday, February 20, 2024 | Dementia

Abstract INTRODUCTION Lifelong bilingualism is associated with a delayed age at onset of dementia, but evidence from community-based studies is limited. We investigated the relationship between bilingualism and the prevalence of cognitive impairment in a...

A pilot study of an intergenerational program for people in residential aged care with cognitive impairment and children from a co-located early learning centre during COVID-19

by Clinical Neuropsychologist Online | Tuesday, February 20, 2024 | Dementia

Dementia, Volume 23, Issue 6, Page 927-948, August 2024. Intergenerational programs in residential aged care may improve well-being and combat loneliness and social isolation in older people with cognitive impairment. This pilot study investigated the effects of a...

Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, February 20, 2024 | Dementia

Abstract INTRODUCTION The most significant genetic risk factor for late-onset Alzheimer’s disease (AD) is APOE4, with evidence for gain- and loss-of-function mechanisms. A clinical need remains for therapeutically relevant tools that potently modulate APOE...

General cognitive ability in high school, attained education, occupational complexity, and dementia risk

by Clinical Neuropsychologist Online | Tuesday, February 20, 2024 | Dementia

Abstract INTRODUCTION We address the extent to which adolescent cognition predicts dementia risk in later life, mediated by educational attainment and occupational complexity. METHODS Using data from Project Talent Aging Study (PTAS), we fitted two structural equation...