Hippocampal snRNA‐seq in Collaborative Cross reveals molecular signatures of cognitive resilience independent of chronological aging

by Clinical Neuropsychologist Online | Thursday, September 17, 2026 | Dementia

Abstract INTRODUCTION Genetic factors contribute to variability in age-related cognitive decline, yet the molecular mechanisms underlying cognitive resilience remain poorly understood. METHODS We performed single-nucleus RNA sequencing on hippocampal tissue from 107...

MARBLE: An in vivo MRI marker of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC)

by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia

Abstract INTRODUCTION Limbic-predominant age-related transactive response DNA binding protein 43 kDa encephalopathy neuropathologic change (LATE-NC) is common in older adults, yet definitive diagnosis is only possible at autopsy. METHODS This work developed a fully...

Incidence of dementia and mild cognitive impairment in two Indigenous Bolivian cohorts

by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia

Abstract INTRODUCTION We studied dementia incidence and risk factors in Indigenous Tsimane and Moseten Amerindian populations in Amazonian Bolivia with largely subsistence lifestyles. METHODS A median of 4.7 years after baseline dementia assessment, 730 participants...

Genetic and molecular evidence linking CTSH to Alzheimer’s disease pathophysiology

by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia

Abstract INTRODUCTION Lysosomal dysfunction contributes to Alzheimer’s disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is...

Digital cognitive phenotyping enhances risk stratification in preclinical Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia

Abstract INTRODUCTION Amyloid positivity does not reliably predict near-term cognitive decline in preclinical Alzheimer’s disease (AD). We tested whether digital cognitive phenotyping improves prognostic precision. METHODS Baseline performance on a brief...

From heart to mind: A narrative review of incidence, risk factors, and mechanisms of dementia after cardiac surgery

by Clinical Neuropsychologist Online | Tuesday, September 15, 2026 | Dementia

Abstract As cardiac surgery becomes more common, concerns about postoperative cognitive decline and the potential progression to dementia have grown. While postoperative cognitive dysfunction (POCD) is well documented, its relationship to long-term dementia risk...