Tau‐related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is influenced by Aβ

by Clinical Neuropsychologist | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION Positron emission tomography (PET) imaging studies have shown that amyloid beta (Aβ) is significantly correlated with glucose metabolism in mild cognitive impairment independently of the apolipoprotein E (APOE) ε4 genotype. METHODS We used a...

Characterizing the olfaction and dementia association in the community‐based ARIC study

by Clinical Neuropsychologist | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION Few studies have characterized the association of olfaction with dementia in detail across diverse sociodemographic subgroups. METHODS We examined the association of one-time-point olfactory status with incident dementia overall and by age, race,...

Longitudinal patterns of brain aging and neurodegeneration among older adults with dual decline in memory and gait

by Clinical Neuropsychologist | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION Dual cognitive and mobility decline is more strongly associated with dementia risk than cognitive decline only. It remains unknown whether this syndrome is associated with brain atrophy patterns, white matter (WM) damage, or pathology. METHODS In...

Disclosure of elevated amyloid status is not associated with long‐term suicidality in a preclinical AD trial

by Clinical Neuropsychologist | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION The long-term implications of disclosing Alzheimer’s disease (AD) biomarker information to cognitively unimpaired individuals are unknown. METHODS We compared participants who disclosed their elevated amyloid imaging result in a preclinical...

Patterns of sick leave and unemployment prior to a diagnosis of young onset Alzheimer’s disease

by Clinical Neuropsychologist | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION Early symptoms in young onset Alzheimer’s disease (YOAD) may be misinterpreted, causing delayed diagnosis. This population-based study aimed to map adverse occupational events preceding YOAD diagnosis as potential prodromal signs. METHODS...

Moderation of midlife cognitive activity on tau‐related cognitive impairment

by Clinical Neuropsychologist | Monday, February 24, 2025 | Dementia

Abstract INTRODUCTION We investigated the moderating effects of midlife and late-life cognitive activity (CA) on the relationship between tau pathology and both cognition and cognitive decline. METHODS Eighty-nine non-demented older adults from a Korean cohort...