by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Dementia
Abstract INTRODUCTION Patterns of signal from tau positron emission tomography (tau-PET) confined to the medial temporal lobe (MTL) or extended into the neocortex may be relevant for Alzheimer’s disease (AD) research if they are linked to differential biomarker...
by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Dementia
Abstract INTRODUCTION Progression to Alzheimer’s disease (AD) dementia from normal cognition (NC) can follow different trajectories, with most progressing through a recognizable mild cognitive impairment stage (NC–MCI–AD), while some individuals transition...
by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Dementia
Abstract INTRODUCTION Neighborhood environments may promote neurocognitive health in part by providing amenities that encourage physical activity. We examined associations between quantity of walkable facilities, including specifically physical activity facilities...
by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Dementia
Abstract INTRODUCTION It remains unclear whether the local amyloid-beta (Aβ) burden in key regions within the default mode network (DMN) affects network and cognitive functions. METHODS Participants included 1002 individuals from the Chinese Preclinical...
by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Dementia
Abstract BACKGROUND Approximately 40% of people aged ≥ 65 experience memory loss, particularly in episodic memory. Identifying the genetic basis of episodic memory decline is crucial for uncovering its underlying causes. METHODS We investigated common and rare genetic...
by Clinical Neuropsychologist | Tuesday, November 19, 2024 | Dementia
Abstract INTRODUCTION A key goal of the Alzheimer’s Disease NeuroImaging Initiative (ADNI) positron emission tomography (PET) Core is to harmonize quantification of β-amyloid (Aβ) and tau PET image data across multiple scanners and tracers. METHODS We developed...
