by Clinical Neuropsychologist | Saturday, February 22, 2025 | Dementia
Abstract INTRODUCTION Isolated REM sleep behavior disorder (iRBD) is a strong prodromal marker of Lewy body diseases (LBDs) – Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Cholinergic loss is linked to cognitive decline in these conditions, but...
by Clinical Neuropsychologist | Saturday, February 22, 2025 | Dementia
Abstract INTRODUCTION Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost and accessibility barriers. METHODS We thoroughly investigated...
by Clinical Neuropsychologist | Saturday, February 22, 2025 | Dementia
Abstract INTRODUCTION Human herpesvirus (HHV) has been linked to Alzheimer’s disease (AD), but the underlying mechanisms remain unknown. METHODS We leveraged functional genomics data from Religious Orders Study or the Rush Memory and Aging Project (ROS/MAP) and...
by Clinical Neuropsychologist | Saturday, February 22, 2025 | Dementia
Abstract Hippocampal atrophy on magnetic resonance imaging is an important biomarker in Alzheimer’s disease (AD). While hippocampal atrophy was thought to result from tau tangles in AD, different neuropathologies can lead to hippocampal atrophy, especially TAR...
by Clinical Neuropsychologist | Saturday, February 22, 2025 | Dementia
Abstract INTRODUCTION Specific features of subjective cognitive decline (SCD-plus) have been proposed to indicate an increased risk of preclinical Alzheimer’s disease (AD). However, few studies have examined how these features relate to AD biomarkers in...
by Clinical Neuropsychologist | Thursday, February 20, 2025 | Dementia
Abstract Neurodegenerative diseases (NDDs) pose a significant challenge in modern medicine due to their clinical heterogeneity, multifactorial etiologies, and frequent co-pathologies. Traditional diagnostic systems, based on clinical symptoms and post mortem findings,...
