by Clinical Neuropsychologist | Tuesday, January 14, 2025 | Dementia
Abstract INTRODUCTION Successful cognitive aging is related to both maintaining brain structure and avoiding Alzheimer’s disease (AD) pathology, but how these factors interplay is unclear. METHODS A total of 109 cognitively normal older adults (70+ years old)...
by Clinical Neuropsychologist | Tuesday, January 14, 2025 | Dementia
Abstract INTRODUCTION Interferon-induced transmembrane protein 3 (IFITM3) modulates γ-secretase in Alzheimer’s Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell-specific effect on AD remains unclear. METHODS Single...
by Clinical Neuropsychologist | Friday, January 10, 2025 | Dementia
Abstract BACKGROUND We sought to characterize the cognitive profile among individuals with mild cognitive impairment with Lewy bodies (MCI-LB) to help guide future clinical criteria. METHODS Systematic review and meta-analysis included MCI-LB studies with cognitive...
by Clinical Neuropsychologist | Thursday, January 9, 2025 | Dementia
Abstract INTRODUCTION Menopausal hormone therapy (MHT), along with the apolipoprotein E (APOE) ε4 allele, has been suggested as a possible risk factor for Alzheimer’s disease (AD). However, the relationship between MHT and cerebrospinal fluid (CSF) biomarkers is...
by Clinical Neuropsychologist | Thursday, January 9, 2025 | Dementia
Abstract Background We analyzed the clinical care pathway of patients from symptom development to diagnosis at varying stages of Alzheimer’s disease (AD) to understand the path and barriers to diagnosis. Methods Data were from the US Adelphi Real World Dementia...
by Clinical Neuropsychologist | Thursday, January 9, 2025 | Dementia
Abstract Background Insulin Resistance (IR) is implicated in brain aging and Alzheimer’s disease (AD) pathogenesis. Dietary changes may promote brain health in older adults with metabolic abnormalities. An extensive animal literature suggests pro-cognitive and...
