Longitudinal functional network connectivity changes across the clinical stages of C9orf72 hexanucleotide repeat expansion carriers

by Clinical Neuropsychologist Online | Monday, August 31, 2026 | Dementia

Abstract INTRODUCTION Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross-sectional abnormalities and longitudinal...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer’s disease progression

by Clinical Neuropsychologist Online | Sunday, August 30, 2026 | Dementia

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p-tau217) in Alzheimer’s disease (AD) remains uncertain. METHODS In this multi-cohort study of 2117 individuals, we established baseline plasma p-tau217...

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer’s disease

by Clinical Neuropsychologist Online | Sunday, August 30, 2026 | Dementia

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer’s disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in...

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

by Clinical Neuropsychologist Online | Sunday, August 30, 2026 | Dementia

Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and...

Reconstructing Identity in the Shadow of Dementia: Narrative Identity Processes Among Adult Child Caregivers

by Clinical Neuropsychologist Online | Thursday, August 27, 2026 | Dementia

Dementia, Ahead of Print. Caring for a parent with dementia constitutes a profound relational and existential transition for adult children, extending beyond functional caregiving demands to processes of identity negotiation and reconstruction. Although extensive...

“You Don’t Belong in Hospital”: How Hospital-Based Dementia Stigma Shapes Health-Related Quality of Life

by Clinical Neuropsychologist Online | Thursday, August 27, 2026 | Dementia

Dementia, Ahead of Print. Health-related quality of life reflects individuals’ perceptions of how a health condition affects their physical, psychological, and social functioning. Amid increasing pressures on primary care systems, people living with dementia are...