Longitudinal effects of physical activity on sleep in association with hippocampal‐amygdala subfield structure and functional connectivity in Alzheimer’s disease

Abstract INTRODUCTION Sleep is a modifiable risk factor in Alzheimer’s disease (AD), but its relationship to medial temporal lobe (MTL) subfields and responsiveness to lifestyle interventions remain unclear. METHODS In the Dementia-Multi-Objective Validation of...

Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer’s disease neuropathology: Preliminary observations

Abstract INTRODUCTION Down syndrome (DS) is caused by a complete or partial trisomy of chromosome 21, resulting in variable intellectual disabilities and a high risk for early-onset Alzheimer’s disease (DS-AD). Dysregulation of the mammalian target of rapamycin...