Phenotypic and genetically predicted sleep traits in relation to dementia incidence in Swedish twins

by Clinical Neuropsychologist Online | Monday, November 9, 2026 | Dementia

Abstract INTRODUCTION Sleep and dementia are complex phenotypes shaped by genetic and environmental factors, but the genetic contribution of sleep to dementia risk remains unclear. This study examined associations of both phenotypic and genetically predicted sleep...

Age‐linked biological context shapes adaptive immunity in Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, November 6, 2026 | Dementia

Abstract Alzheimer’s disease (AD) is increasingly recognized as a neuroimmune disorder with protective or pathogenic adaptive immunity dependent on the biological context. This review synthesizes evidence from human studies, genetic analyses, mouse models, and...

Coronary artery disease and cardiac pathology in cerebral small vessel disease and post‐stroke dementia: Implications for Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, November 6, 2026 | Dementia

Abstract BACKGROUND The relationships between coronary or cardiac pathology, cerebral small vessel disease (SVD), Alzheimer’s disease pathology, and vascular cognitive impairment and dementia (VCID) remain unclear. METHODS We performed a clinicopathological...

Highlighting TaRget Enablement to Accelerate Therapy Development for Alzheimer’s Disease (TREAT‐AD) centers

by Clinical Neuropsychologist Online | Friday, November 6, 2026 | Dementia

Alzheimer’s &Dementia, Volume 22, Issue 11, November 2026. If you do not see content above, kindly GO TO SOURCE. Not all publishers encode content in a way that enables republishing at Neuro.vip. This post is Copyright: | November 6, 2026 Neuro-Dementia...

Push–pull hypothesis of Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, November 6, 2026 | Dementia

Abstract The “push–pull” hypothesis of Alzheimer’s disease (AD) emerges from a careful examination of the key discoveries over the past 40 years. Specifically, amyloid beta (Aβ) plays a direct role impairing endolysosome activity in neurons and microglia,...

Disease progression in probable limbic‐predominant age‐related TDP‐43 encephalopathy

by Clinical Neuropsychologist Online | Friday, November 6, 2026 | Dementia

Abstract INTRODUCTION Limbic-predominant age-related transactive response DNA-binding protein of 43 kDa (TDP-43) encephalopathy (LATE) is confirmed in post mortem examination by TDP-43 pathology. Applying certain criteria, we examined cognitive trajectories in...