Integrative prediction of Alzheimer’s disease and related dementias using multi‐omics aging clocks and genetic data

by Clinical Neuropsychologist Online | Monday, September 28, 2026 | Dementia

Abstract INTRODUCTION We tested whether combining Alzheimer’s disease and related dementias (ADRD) polygenic risk scores (PRS) with biological aging markers improves ADRD risk prediction. METHODS In 16,215 UK Biobank (UKB) participants free of ADRD at baseline...

Precision residential greenspace, urban environmental exposures, and incident dementia among older adults in Sweden: A 16‐year cohort study

by Clinical Neuropsychologist Online | Monday, September 28, 2026 | Dementia

Abstract INTRODUCTION Residential greenspace is linked to mental and cardiometabolic health, but longitudinal studies on detailed greenspace and dementia incidence are limited. METHODS We followed 2993 dementia-free participants in the Swedish National Study on Aging...

TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia

Abstract INTRODUCTION Microglia-mediated clearance of amyloid beta (Aβ) is crucial for mitigating Alzheimer’s disease (AD) progression, yet the molecular regulators of microglial phagocytosis remain incompletely understood. METHODS We assessed AD-related...

Technology‐natives and technology‐adopters: Age differences in remote cognitive assessment in Alzheimer disease

by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia

Abstract INTRODUCTION Cognitive changes in the asymptomatic stages of Alzheimer disease (AD) are subtle and difficult to detect using conventional cognitive tests. High-frequency smartphone-based testing may improve sensitivity to these changes, but generational...

Mapping sex‐specific associations of adiposity with age‐related cognitive decline and multimodal Alzheimer’s pathology

by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia

Abstract INTRODUCTION The adiposity–cognition relationship in aging is controversial. This study aimed to assess its sex- and age-specific associations with Alzheimer’s disease (AD) pathology using multimodal biomarkers. METHODS In two longitudinal cohorts (Hubei...

Platelet count polygenic scores may modify the effect of aspirin in primary prevention of dementia

by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia

Abstract INTRODUCTION Aspirin is not recommended for dementia prevention due to limited benefit. We investigated whether genetic subgroups may benefit. METHODS In the ASPirin in Reducing Events in the Elderly (ASPREE) trial (n = 13,541), we screened 5182 polygenic...