MRI‐derived glymphatic‐related composite captures brain and cognitive vulnerability associated with cardiovascular risk in older adults

by Clinical Neuropsychologist Online | Sunday, November 1, 2026 | Dementia

Abstract INTRODUCTION We evaluated a multimodal magnetic resonance imaging (MRI)-derived glymphatic-related composite and examined its associations with cardiovascular risk, brain structural integrity, and cognition in older adults. METHODS Ninety-two participants...

Tau positron emission tomography harmonization using the CenTauR approach: General conversion equations, relevant cut‐points, and external validation

by Clinical Neuropsychologist Online | Friday, October 30, 2026 | Dementia

Abstract INTRODUCTION Tau positron emission tomography (PET) tracers differ in kinetics, binding properties, and quantification pipelines, complicating cross-study comparisons. The CenTauR approach provides a unified framework for harmonizing tau PET quantification...

Polygenic risk scores for LATE‐neuropathologic change: Implications for clinical utility

by Clinical Neuropsychologist Online | Friday, October 30, 2026 | Dementia

Abstract INTRODUCTION Limbic-predominant age-related TDP-43 encephalopathy (LATE) exhibits clinical features resembling Alzheimer’s disease (AD) and frequently occurs as a co-pathology, yet there are fewer biomarkers for LATE relative to AD. METHODS We...

Expert perspectives on the design and communication of endpoints in Alzheimer’s disease clinical trials

by Clinical Neuropsychologist Online | Friday, October 30, 2026 | Dementia

Abstract Disease-targeted therapies (DTTs) for Alzheimer’s disease (AD) represent a major advance, yet challenges remain on how best to interpret and communicate their benefits. As clinical development increasingly targets the earliest stages of AD (before...

Retinal microvasculature alterations are associated with mild behavioral impairment in Southeast Asian dementia‐free older adults

by Clinical Neuropsychologist Online | Friday, October 30, 2026 | Dementia

Abstract BACKGROUND Mild behavioral impairment (MBI) is an important neurobehavioral marker of dementia. This study examined associations between retinal vascular measures, MBI, and its potential neurobiological correlates. METHODS Dementia-free older adults from a...

Deep learning‐based prediction of regional brain Tau PET burden from MRI

by Clinical Neuropsychologist Online | Friday, October 30, 2026 | Dementia

Abstract INTRODUCTION Regional tau is strongly associated with Alzheimer’s disease (AD) symptoms, but tau positron emission tomography (PET) is not routinely available, limiting early risk stratification. METHODS We trained a deep learning model to predict...