by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia
Abstract INTRODUCTION Vascular risk factors (VRFs) contribute to white matter microstructural degeneration, but their tract-specific contributions are unclear. We assessed the independent associations of four major VRFs with white matter microstructure in a large,...
by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia
Abstract INTRODUCTION While most studies of Alzheimer’s disease (AD) examine cross-sectional relationships among biomarkers, longitudinal relationships are also highly relevant. METHODS This study in the Alzheimer’s Disease Neuroimaging Initiative cohort...
by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia
Abstract INTRODUCTION Plasma phosphorylated tau 217 (p-tau217) is a promising biomarker for monitoring treatment response in Alzheimer’s disease (AD), but its longitudinal dynamics and clinical relevance remain unclear. METHODS In this prospective real-world...
by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia
Abstract Mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease (AD), remains undiagnosed in > 90% of individuals, delaying access to timely evaluation and interventions. Self-administered digital cognitive assessments (SA-DCAs) offer...
by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia
Abstract INTRODUCTION Although tau positron emission tomography (PET) imaging is effective for staging tau pathology, it is limited clinically by cost and availability. Machine learning models based on magnetic resonance imaging (MRI)– and amyloid PET–derived features...
by Clinical Neuropsychologist Online | Friday, July 31, 2026 | Dementia
Dementia, Ahead of Print. Sexuality plays an important role for couples confronted with dementia and may support them to cope with the disease, to sustain the couple relationship and sustain a better experience of the caregiving situation. Nevertheless, the majority...
