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Designing for Dementia: A Multiple Case Study Approach to Explore How Care Home Environments May Influence Wandering

by Clinical Neuropsychologist Online | Saturday, July 11, 2026 | Dementia

Dementia, Ahead of Print. Up to 60% of people living with dementia ‘wander’ in care homes. Previously perceived negatively, wandering is increasingly recognised as a meaningful activity, driven by enjoyment, routine, and social connection. Care home environments can...

Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study

by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia

Abstract INTRODUCTION Longitudinal studies linking sedentary behavior (SB) in different contexts to brain structure and white matter hyperintensity (WMH) volume remain limited. METHODS We analyzed data from the Atherosclerosis Risk in Communities (ARIC) study...

Does lifestyle intervention lower clinically significant cognitive impairment risk?

by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia

Abstract INTRODUCTION Multidomain lifestyle interventions have been demonstrated to benefit cognitive function but it is unknown whether they reduce risk for clinically significant cognitive impairment sCI (mild cognitive impairment or dementia). METHODS The Action...

Genetically linked brain imaging markers of memory decline in aging and Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia

Abstract INTRODUCTION Memory is a strong endophenotype for Alzheimer’s disease (AD) but is typically detectable only after substantial brain change. Genetically linking late-life memory with mid-life brain traits may identify early markers of AD-related...

Safety considerations of gene‐based therapies for Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia

Abstract Gene-based therapies show increasing promise for the treatment of neurologic disease. In 2016, nusinersen, an RNA-based therapy, was approved for children with spinal muscular atrophy (SMA). Over 200 clinical trials have utilized gene therapy approaches for a...

The patient journey for people with dementia and their carers in Peru: From first symptoms to diagnosis and treatment

by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia

Abstract INTRODUCTION We explored how people with dementia (PwD) and their carers navigate Peru’s health system for diagnosis and treatment. METHODS We interviewed PwD (n = 4), carers (n = 18), and healthcare workers (n = 17) from four sites. We developed a...
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