The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, October 16, 2026 | Dementia

Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer’s disease...

Attention‐deficit/hyperactivity disorder polygenic risk score and incidence of cognitive impairment in older adults: A prospective multicohort study

by Clinical Neuropsychologist Online | Thursday, October 15, 2026 | Dementia

Abstract INTRODUCTION Preliminary evidence suggests a link between attention-deficit/hyperactivity disorder (ADHD) and later-life cognitive impairment. Whether genetic risk for ADHD, estimated using an ADHD polygenic risk score (ADHD-PRS), is associated with incident...

Perceptions of Dementia Prevention on YouTube: A Thematic Analysis of Viewer Comments

by Clinical Neuropsychologist Online | Thursday, October 15, 2026 | Dementia

Dementia, Ahead of Print. Dementia prevention is receiving increasing attention considering the surge in number of dementia incidence worldwide. Although there are modifiable risk factors, the public remains largely unaware of dementia prevention. Many individuals...

Air pollution is associated with sex‐specific longitudinal changes in astrocytic and neuroinflammatory processes linked to cognitive decline in Alzheimer’s disease at‐risk individuals

by Clinical Neuropsychologist Online | Wednesday, October 14, 2026 | Dementia

Abstract INTRODUCTION Air pollution is associated with dementia risk, but its role during preclinical Alzheimer’s disease (AD) remains unclear. METHODS We examined long-term residential exposure to traffic-related air pollution in 226 cognitively unimpaired...

Brain microstructure mediates the relationship between Alzheimer’s proteinopathies and memory

by Clinical Neuropsychologist Online | Tuesday, October 13, 2026 | Dementia

Abstract INTRODUCTION We examined how amyloid beta (Aβ) and tau accumulation affected gray matter (GM) microstructural integrity and how such alterations impacted memory. METHODS We tested voxel-wise mediation models to examine the relationships between (1) positron...

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue

by Clinical Neuropsychologist Online | Tuesday, October 13, 2026 | Dementia

Abstract INTRODUCTION Metabolic dysregulation is a hallmark of Alzheimer’s disease (AD), with numerous studies characterizing metabolic pathways associated with AD onset and progression. A limitation of these studies has been a focus on non-Hispanic white...