SORL1 variant links endosomal amyloid precursor protein mis‐sorting to axonal transport defects and neuronal dysfunction

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Abstract INTRODUCTION SORL1 encodes the sorting receptor SORLA, a major genetic contributor to Alzheimer’s disease (AD). Although SORL1 loss disrupts endosomal trafficking and promotes amyloidogenic amyloid precursor protein (APP) processing, the functional...

Joint changes in subjective memory and objective cognition and risk of incident functional dependence: A harmonized analysis of four aging cohorts

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Concordant subjective-memory and objective-cognition decline showed the strongest and most reproducible association with incident functional dependence across four aging cohorts. Abstract INTRODUCTION The prognostic value of concurrent changes in subjective memory and...

Beyond amyloid: Contributions of neuroinflammation, cerebrovascular disease, and neurodegeneration to memory impairment in the oldest‐old, the LifeAfter90 Study

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Abstract INTRODUCTION Neuroinflammatory processes may play a central role in promoting mixed pathologies and cognitive impairment in the oldest-old. We hypothesize that elevated neuroinflammation, indicated by reactive astrocytosis, acts on cerebrovascular disease and...

Integrated digit‐in‐noise testing for hearing and cognitive screening

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Abstract INTRODUCTION Hearing loss and cognitive decline often coexist in aging, and reduced audibility can bias cognitive screening. We evaluated integrated digit-in-noise (iDIN) testing for paired screening. METHODS Among 962 community-screened adults 55 years of...

Aberrant ɑSMA expression reveals broad mossy fiber reorganization integrating with tangle and plaque formation and mitoenergetic alteration in the human hippocampus

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Abstract INTRODUCTION Neural network and bioenergetic abnormalities occur with Alzheimer’s disease (AD) pathogenesis. METHODS We explored mossy fiber (MF) and mitoenergetic alteration using ɑ-smooth muscle actin (ɑSMA) and cytochrome c oxidase (COX)...

The effects of bariatric surgery on dementia in patients with diabetes and obesity

by Clinical Neuropsychologist Online | Saturday, August 22, 2026 | Dementia

Abstract INTRODUCTION Type 2 diabetes (T2D) and obesity are among the most important risk factors for dementia. Although weight loss is an important preventive strategy, the impact of metabolic and bariatric surgery (MBS) on dementia risk remains contradictory....