Nuclear dysfunction in aging and neurodegeneration

by Clinical Neuropsychologist Online | Sunday, July 12, 2026 | Dementia

Abstract Neurodegenerative diseases are characterized by a loss of neuronal function and structure, often in a region-specific manner. Multiple factors contribute to neuronal dysfunction and death, including pathogenic protein buildup, protein mislocalization, and...

Adoption of Alzheimer’s disease biomarkers by primary care clinicians: findings from the National Dementia Workforce Study

by Clinical Neuropsychologist Online | Sunday, July 12, 2026 | Dementia

Abstract INTRODUCTION Biomarkers for Alzheimer’s disease (AD) are now available for clinical use; however, little is known about their use in primary care. METHODS Cross-sectional analysis of 2024 data from the National Dementia Workforce Study, a nationally...

Designing for Dementia: A Multiple Case Study Approach to Explore How Care Home Environments May Influence Wandering

by Clinical Neuropsychologist Online | Saturday, July 11, 2026 | Dementia

Dementia, Ahead of Print. Up to 60% of people living with dementia ‘wander’ in care homes. Previously perceived negatively, wandering is increasingly recognised as a meaningful activity, driven by enjoyment, routine, and social connection. Care home environments can...

Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study

by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia

Abstract INTRODUCTION Longitudinal studies linking sedentary behavior (SB) in different contexts to brain structure and white matter hyperintensity (WMH) volume remain limited. METHODS We analyzed data from the Atherosclerosis Risk in Communities (ARIC) study...

Does lifestyle intervention lower clinically significant cognitive impairment risk?

by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia

Abstract INTRODUCTION Multidomain lifestyle interventions have been demonstrated to benefit cognitive function but it is unknown whether they reduce risk for clinically significant cognitive impairment sCI (mild cognitive impairment or dementia). METHODS The Action...

Genetically linked brain imaging markers of memory decline in aging and Alzheimer’s disease

by Clinical Neuropsychologist Online | Friday, July 10, 2026 | Dementia

Abstract INTRODUCTION Memory is a strong endophenotype for Alzheimer’s disease (AD) but is typically detectable only after substantial brain change. Genetically linking late-life memory with mid-life brain traits may identify early markers of AD-related...