Why sleep assessment belongs in the memory clinic

by Clinical Neuropsychologist Online | Monday, October 26, 2026 | Dementia

Abstract Sleep disturbances are highly prevalent in older adults and are particularly common among individuals attending memory clinics for assessment of cognitive impairment. Emerging evidence links sleep disorders, including insomnia, obstructive sleep apnea,...

Tau extent is associated with lower cognition in Down syndrome‐related Alzheimer’s disease

by Clinical Neuropsychologist Online | Sunday, October 25, 2026 | Dementia

Abstract INTRODUCTION 18F-MK6240 is a second-generation tau positron emission tomography (PET) tracer with high dynamic range able to detect early tau pathology in Alzheimer’s disease, however, its binding characteristics have not been evaluated in Down syndrome...

Blood transcriptomic signatures of vascular risk in Alzheimer’s disease

by Clinical Neuropsychologist Online | Sunday, October 25, 2026 | Dementia

Abstract INTRODUCTION Lifestyle and environmental factors contributing to cardiovascular risk are components of the exposome, yet molecular signatures associated with cumulative cardiovascular risk in Alzheimer’s disease (AD) remain incompletely understood....

Vascular drivers of cerebrospinal fluid movement and enlarged perivascular spaces

by Clinical Neuropsychologist Online | Sunday, October 25, 2026 | Dementia

Abstract Perivascular spaces (PVSs) facilitate cerebrospinal fluid flow and waste clearance, which are critical for maintaining brain homeostasis. Enlarged PVSs (ePVSs) are an emerging marker of cerebral small vessel disease and are implicated in protein accumulation,...

Outdoor extreme heat‐related dementia risk and the role of socioeconomic disparities: evidence from 20 years of data on US older adults

by Clinical Neuropsychologist Online | Thursday, October 22, 2026 | Dementia

Abstract INTRODUCTION Extreme heat is increasingly recognized as a significant threat to brain health. However, human evidence from large, longitudinal studies remains limited. We examine whether outdoor heat exposure is associated with incident dementia and whether...

Cerebral blood flow as a biomarker of resilience in cognitively unimpaired APOE ɛ4 carriers

by Clinical Neuropsychologist Online | Thursday, October 22, 2026 | Dementia

Abstract INTRODUCTION It remains unclear whether medial temporal lobe (MTL) hyperperfusion in cognitively unimpaired apolipoprotein E (APOE) ɛ4 carriers reflects resilience or dysfunction. We examined whether cortical MTL cerebral blood flow (CBF) relates to cognition...