Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer’s disease

by Clinical Neuropsychologist Online | Sunday, August 30, 2026 | Dementia

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer’s disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in...

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

by Clinical Neuropsychologist Online | Sunday, August 30, 2026 | Dementia

Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and...

Reconstructing Identity in the Shadow of Dementia: Narrative Identity Processes Among Adult Child Caregivers

by Clinical Neuropsychologist Online | Thursday, August 27, 2026 | Dementia

Dementia, Ahead of Print. Caring for a parent with dementia constitutes a profound relational and existential transition for adult children, extending beyond functional caregiving demands to processes of identity negotiation and reconstruction. Although extensive...

“You Don’t Belong in Hospital”: How Hospital-Based Dementia Stigma Shapes Health-Related Quality of Life

by Clinical Neuropsychologist Online | Thursday, August 27, 2026 | Dementia

Dementia, Ahead of Print. Health-related quality of life reflects individuals’ perceptions of how a health condition affects their physical, psychological, and social functioning. Amid increasing pressures on primary care systems, people living with dementia are...

Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer’s disease through machine learning and transcriptomic integration

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract INTRODUCTION Functional brain network alterations associated with Alzheimer’s disease (AD) pathology, including amyloid beta (Aβ) and phosphorylated tau (p-tau), are difficult to interpret due to overlapping aging-associated and non-amyloid biological...

Estimating treatment effects in clinical studies of Alzheimer’s disease: What are estimands and why do we need them?

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract In clinical studies, it is scientifically important, and a regulatory expectation, that objectives be translated into key clinical questions by specifically defining treatment effects to be estimated. Estimands are part of a structured framework, as presented...