Social engagement and brain structure‐informed cognitive domain trajectories in older adults: The National Health and Aging Trends Study

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia

Abstract INTRODUCTION Cognitive decline may emerge in specific domains before overt dementia, yet domain-specific cognitive benefits of social engagement remain unclear. METHODS Using National Health and Aging Trends Study (NHATS) data (2011–2019) from 6,084...

Vulnerability of locus coeruleus connections to aging and Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia

Abstract INTRODUCTION The locus coeruleus (LC) is important in coordinating communication between brain regions through its widespread connections. However, the organization of its connections, and its changes with aging and Alzheimer’s disease (AD), remains...

CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia

Abstract INTRODUCTION Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals...

Inhibition of Moesin and CD44 in stem cell‐derived neurons affects the pathological genetic signature associated with Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia

Abstract INTRODUCTION Post mortem proteomic analysis of Alzheimer’s disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced...

“If She’s Anything Like Me…”: Exploring the Use of Verbally-Prompted Storytelling Techniques in Research With People Living With Dementia

by Clinical Neuropsychologist Online | Wednesday, August 12, 2026 | Dementia

Dementia, Ahead of Print. Although approaches exist to address challenges in supporting participation of people living with dementia in research, these approaches are rarely evaluated, a critical step to understand their influence on promoting the engagement of people...

Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, August 11, 2026 | Dementia

Abstract Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer’s disease (AD) risk. In this Perspective article, we propose a stage-informed...