Hormone replacement therapy and dementia risk among postmenopausal women: Identifying responsive subgroups in the UK Biobank

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract INTRODUCTION Modifiers of the association between hormone replacement therapy (HRT) use and dementia risk and responsive subgroups, are unknown. METHODS In 183,450 postmenopausal women from the UK Biobank (mean 13.3 years follow-up), multivariable Cox...

APOE‐guided lecanemab dosing dissociates ARIA‐E from ARIA‐H: The K‐ROAD study

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract INTRODUCTION We evaluated whether apolipoprotein E (APOE εε4) genotype-guided lecanemab escalation mitigates the APOE εε4–driven amyloid-related imaging abnormalities (ARIA) with edema (ARIA-E) gradient and whether ARIA-E and ARIA with hemosiderin deposition...

Chronic stress, social support, and domain‐specific cognitive decline in HABS‐HD

by Clinical Neuropsychologist Online | Wednesday, August 26, 2026 | Dementia

Abstract INTRODUCTION Few studies have examined the longitudinal associations between chronic stress, social support, and cognitive decline or whether sociodemographic factors modify associations. METHODS We included 3873 older adults enrolled in the Health and Aging...

When treatment becomes risk: polypharmacy and inappropriate prescribing in cognitive impairment in 2379 consecutive patients from a memory clinic

by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Dementia

Abstract BACKGROUND Polypharmacy, potentially inappropriate medications (PIMs), and drugs associated with drug-induced cognitive impairment (DICI) are highly prevalent in older adults and may affect cognitive decline. METHODS This observational retrospective study...

Retinal microvascular alterations and glymphatic dysfunction mediate the association between APOE ε4 and cognitive decline in Alzheimer’s disease

by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Dementia

Abstract BACKGROUND Vascular and glymphatic dysfunction are increasingly implicated in Alzheimer’s disease (AD), particularly among apolipoprotein E (APOE) ε4 carriers. We investigated relationships among retinal microvasculature, glymphatic markers, and AD...

Factors associated with intracerebral hemorrhage in confirmed cerebral amyloid angiopathy

by Clinical Neuropsychologist Online | Tuesday, August 25, 2026 | Dementia

Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is a leading cause of lobar intracerebral hemorrhage (ICH) in the elderly. The influence of apolipoprotein E (APOE) variants, CAA pathology, and concomitant Alzheimer’s disease (AD) neuropathologic changes...