A cell‐type‐resolved meta‐analysis reveals glial DNA methylation changes associated with aging and Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia

Abstract INTRODUCTION Epigenome-wide association studies implicate DNA methylation in Alzheimer’s disease (AD) pathology. Although recent studies identified epigenetic signatures within non-neuronal cell types in disease risk, the role of the methylome in glial...

Transcriptional risk score for chronic kidney disease: relation to Alzheimer’s disease

by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia

Abstract INTRODUCTION Although Alzheimer’s disease (AD) is prevalent in individuals with chronic kidney disease (CKD), the mechanistic link remains unclear. We assessed the impact of CKD transcriptional risk on AD endophenotypes. METHODS We calculated the CKD...

Digital Reminiscence-Based Interventions to Enhance Social Interaction of People With Dementia in Care Homes: A Scoping Review

by Clinical Neuropsychologist Online | Thursday, September 24, 2026 | Dementia

Dementia, Ahead of Print. The use of digital tools in reminiscence interventions has increased in recent years, encompassing multimedia platforms, virtual reality (VR), digital life storybooks, and interactive applications. Yet, evidence regarding the effectiveness of...

Prosocial helping behaviors attenuate accelerated cognitive decline driven by APOE ε4

by Clinical Neuropsychologist Online | Wednesday, September 23, 2026 | Dementia

Abstract INTRODUCTION The apolipoprotein E (APOE) ε4 allele accelerates cognitive decline through multiple biological pathways—including neuroinflammatory, vascular, and stress-regulatory mechanisms—yet few modifiable behaviors counter this genetic vulnerability....

Kidney function and brain health: cognitive and structural signatures across cohorts

by Clinical Neuropsychologist Online | Wednesday, September 23, 2026 | Dementia

Abstract INTRODUCTION Chronic kidney disease (CKD) is linked to cognitive decline, yet the roles of estimated glomerular filtration rate (eGFR) and its variability remain unclear. METHODS We analyzed 6847 adults from two population-based cohorts (the Multimodality...

Synergistic association of insomnia and anxiety with cognitive impairment and dementia in older adults

by Clinical Neuropsychologist Online | Wednesday, September 23, 2026 | Dementia

Abstract INTRODUCTION We investigated the synergistic effects of comorbid insomnia and anxiety on cognitive impairment and dementia and explored the underlying plasma biomarker mechanisms. METHODS We included adults ≥ 60 years from the cross-sectional cohort named The...