Alterations of gut microbiota in Down syndrome and their association with Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Abstract INTRODUCTION Adults with Down syndrome (DS) have a higher risk of Alzheimer’s disease (AD). As gut microbiota (GM) alterations have been reported in AD, we investigated their association with cognitive decline and plasma AD biomarkers in DS. METHODS...

MCH‐Guard: Multimodal machine learning framework for risk stratification of cerebral microhemorrhage risk in the Alzheimer’s Disease Neuroimaging Initiative

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Abstract INTRODUCTION Efficient cerebral microhemorrhage (MCH) monitoring is critical for anti-amyloid therapy safety due to amyloid-related imaging abnormalities with hemosiderin deposition (ARIA-H) risk. We developed MCH-Guard, a multimodal machine-learning...

Age‐friendly environments and incident motoric cognitive risk syndrome in older adults: A prospective cohort study

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Abstract INTRODUCTION Motoric cognitive risk syndrome (MCR) is a predementia condition that predicts multiple adverse health outcomes. Age-friendly environments (AFE) represent a key strategy for promoting healthy aging and may reduce MCR risk. However, little is...

Tau‐associated neuronal loss in the intermediate nucleus of the human hypothalamus, a putative VLPO analog, in progressive supranuclear palsy and Alzheimer’s disease

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Abstract BACKGROUND Sleep phenotypes differ in progressive supranuclear palsy (PSP) and Alzheimer’s disease (AD). The human intermediate nucleus (IntN), a putative ventrolateral preoptic analog, promotes non-rapid eye movement (NREM) sleep, but its...

Shared genetic architecture between DTI‐ALPS traits and neurodegenerative diseases

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Abstract INTRODUCTION Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear. METHODS By integrating genome-wide association datasets...

Psychological impacts of APOE genotype disclosure among Latinos in New York City: a randomized controlled trial

by Clinical Neuropsychologist Online | Wednesday, September 9, 2026 | Dementia

Abstract INTRODUCTION Latinos face increased Alzheimer’s disease (AD) risk but are underrepresented in studies of APOE genotype disclosure. We evaluated the psychological impacts of APOE disclosure in the Información de la Enfermedad de Alzheimer para Latinos...