Human CLOCK enhances neocortical function

by Clinical Neuropsychologist | Monday, June 30, 2025 | Neuroscience

Nature Neuroscience, Published online: 30 June 2025; doi:10.1038/s41593-025-01993-4Regulation of gene expression is a facet of human brain specialization. Here, the authors show that human-like expression of the CLOCK gene in the mouse neocortex enhances cognitive...

Fine-mapping genomic loci refines bipolar disorder risk genes

by Clinical Neuropsychologist | Wednesday, June 25, 2025 | Neuroscience

Nature Neuroscience, Published online: 25 June 2025; doi:10.1038/s41593-025-01998-zThis study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition...

Large-scale high-density brain-wide neural recording in nonhuman primates

by Clinical Neuropsychologist | Monday, June 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 June 2025; doi:10.1038/s41593-025-01976-5Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain. If you do...

Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment

by Clinical Neuropsychologist | Monday, June 23, 2025 | Neuroscience

Nature Neuroscience, Published online: 23 June 2025; doi:10.1038/s41593-025-01988-1Pathological neural communication drives the spread of the epileptic network and contributes to memory impairment in focal epilepsy. The authors show that closed-loop electrical...

A flexible hippocampal population code for experience relative to reward

by Clinical Neuropsychologist | Wednesday, June 11, 2025 | Neuroscience

Nature Neuroscience, Published online: 11 June 2025; doi:10.1038/s41593-025-01985-4Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel...

Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex

by Clinical Neuropsychologist | Tuesday, June 10, 2025 | Neuroscience

Nature Neuroscience, Published online: 10 June 2025; doi:10.1038/s41593-025-01970-xThis study demonstrates that high alcohol concentrations during binge drinking activate a small GABAergic neuronal ensemble in the medial orbitofrontal cortex, which subsequently...