Astrocytic cholesterol jams brain clearance in AD

by Clinical Neuropsychologist Online | Tuesday, May 5, 2026 | Neuroscience

Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02310-3Zhang and colleagues identify astrocytic calcium–cholesterol–AQP4 signaling that drives glymphatic dysfunction in early Alzheimer’s disease (AD). Attenuating this signaling restored...

Discussion: Scrolling and Stress: Is Social Media Making Us More Anxious?

by Clinical Neuropsychologist Online | Tuesday, May 5, 2026 | Neuroscience

Social media platforms such as X, LinkedIn, Instagram, Facebook, and TikTok expose the brain to a continuous stream of emotionally charged information ranging from rewarding and entertaining content to stressful and fear-inducing news. If you do not see content above,...

Stochastic growth and ligand–receptor interaction-mediated stabilization generate stereotyped dendritic arbors

by Clinical Neuropsychologist Online | Monday, May 4, 2026 | Neuroscience

Nature Neuroscience, Published online: 04 May 2026; doi:10.1038/s41593-026-02278-0Stereotyped dendritic arbors arise from stochastic growth and selective stabilization of dendritic branches. Two pools of guidance receptor are required. Ligand-free receptors drive...

Microglia-dependent regulation of fear memory extinction

by Clinical Neuropsychologist Online | Monday, May 4, 2026 | Neuroscience

Nature Neuroscience, Published online: 04 May 2026; doi:10.1038/s41593-026-02286-0Liu et al. show in mice that microglia are recruited to the soma and dendritic processes of fear engram neurons during extinction learning and that they weaken fear memories by...

Phasing out animal research prematurely will maintain gender inequities in medicine

by Clinical Neuropsychologist Online | Monday, May 4, 2026 | Neuroscience

Nature Neuroscience, Published online: 04 May 2026; doi:10.1038/s41593-026-02309-wDecades of male bias in animal research have left female biology critically understudied. Prematurely phasing out animal research would lock this inequity into future biomedicine,...

A communication subspace relays context-dependent actions from human prefrontal to motor cortex

by Clinical Neuropsychologist Online | Friday, May 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 May 2026; doi:10.1038/s41593-026-02290-4Context-dependent behavior selects actions according to task demands. Using direct brain recordings in humans, Binish et al. uncover how coordinated population activity efficiently...